Phenotypes associated with this allele

• Allele Symbol: Hsd11b1^tm1Ggla
• Allele Name: targeted mutation 1, Gareth Lavery
• Allele ID: MGI:5444438
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Hsd11b1^tm1Ggla/Hsd11b1^tm1Ggla Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129P2/OlaHsd * C57BL/6 * DBA	MGI:5444453

Genotype
MGI:5444453

cn1

• Allelic Composition: Hsd11b1^tm1Ggla/Hsd11b1^tm1Ggla; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:189059 )

N • when fed a high fat diet, mice exhibit normal insulin resistance

N • mice fed a high fat diet exhibit normal hepatic lipid accumulation

decreased circulating corticosterone level ( J:189059 )

decreased circulating insulin level ( J:189059 )

• mice fed a high fat diet exhibit less of an increase in insulin levels compared with control mice

increased circulating HDL cholesterol level ( J:189059 )

• when fed a low fat diet

• however, there is no significant difference when mice are fed a high fat diet

abnormal glucose tolerance ( J:189059 )

• mice fed a high fat diet resist glucose intolerance with enhanced glucose clearance compared with control mice

behavior/neurological

abnormal eating behavior ( J:189059 )

• marginally reduced when fed normal chow

endocrine/exocrine glands

enlarged adrenal glands ( J:189059 )

growth/size/body

growth/size/body region phenotype ( J:189059 )

N • whether fed a low fat or high fat diet, mice exhibit normal weight

liver/biliary system

liver/biliary system phenotype ( J:189059 )

N • mice fed a high fat diet exhibit normal hepatic lipid accumulation