Phenotypes associated with this allele

• Allele Symbol: Irx3^tm3.1Hui
• Allele Name: targeted mutation 3.1, Chi-Chung Hui
• Allele ID: MGI:5444473
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Irx3^tm3.1Hui/Irx3^tm3.1Hui Irx5^tm3Hui/Irx5^tm3Hui	Not Specified	MGI:5444485

Genotype
MGI:5444485

cx1

• Allelic Composition: Irx3^tm3.1Hui/Irx3^tm3.1Hui; Irx5^tm3Hui/Irx5^tm3Hui
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:189007 )

• present at E14.5 but absent by E15.5

cardiovascular system

abnormal cardiac outflow tract development ( J:189007 )

• improper orientation at E11.5

• misalignment at E12.5, such that the aorta is oriented toward the right ventricle

abnormal heart development ( J:189007 )

• defects in the growth of septa primum and secundum at E12.5

double outlet right ventricle ( J:189007 )

abnormal heart septum morphology ( J:189007 )

• defects in the growth of septa primum and secundum at E12.5

abnormal interatrial septum morphology ( J:189007 )

• absence of the dorsal mesenchymal protrusion and the septum primum at E12.5

atrial septal defect ( J:189007 )

• at E12.5

atrioventricular septal defect ( J:189007 )

• membranous ventricular septal defect at the level of the AV canal at E12.5