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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Irx5tm3Hui
targeted mutation 3, Chi-Chung Hui
MGI:5444483
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Irx3tm3Hui/Irx3tm3Hui
Irx5tm3Hui/Irx5tm3Hui
Isl1tm1(cre)Sev/Isl1+ 		involves: 129S/Sv MGI:5444491
cn2
 		Irx3tm3Hui/Irx3tm3Hui
Irx5tm3Hui/Irx5tm3Hui
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: C57BL/6J * CBA/J MGI:5444486
cn3
 		Irx3tm3Hui/Irx3tm3Hui
Irx5tm3Hui/Irx5tm3Hui
Tg(Tek-cre)1Ywa/0 		involves: C57BL/6 * SJL MGI:5444490
cn4
 		Irx3tm3Hui/Irx3tm3Hui
Irx5tm3Hui/Irx5tm3Hui
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+ 		involves: FVB MGI:5444495
cn5
 		Irx3tm3Hui/Irx3tm3Hui
Irx5tm3Hui/Irx5tm3Hui
Tg(Nkx2-5-cre)9Eno/0 		Not Specified MGI:5444489
cn6
 		Irx3tm3Hui/Irx3tm3Hui
Irx5tm3Hui/Irx5tm3Hui
Tg(Mef2c-cre)#Blk/0 		Not Specified MGI:5444487
cx7
 		Irx3tm3.1Hui/Irx3tm3.1Hui
Irx5tm3Hui/Irx5tm3Hui 		Not Specified MGI:5444485


Genotype
MGI:5444491
cn1
Allelic
Composition		 Irx3tm3Hui/Irx3tm3Hui
Irx5tm3Hui/Irx5tm3Hui
Isl1tm1(cre)Sev/Isl1+
Genetic
Background		 involves: 129S/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irx3tm3Hui mutation (0 available); any Irx3 mutation (25 available)
Irx5tm3Hui mutation (0 available); any Irx5 mutation (31 available)
Isl1tm1(cre)Sev mutation (1 available); any Isl1 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal cardiac outflow tract development ( J:189007 )
• phenocopies abnormalities seen in germ line double null mice
abnormal interatrial septum morphology ( J:189007 )
• absence of the dorsal mesenchymal protrusion and the septum primum
atrial septal defect ( J:189007 )
• appears to be due to a defect in the fusion between the atrioventricular endocardial cushions and the dorsal mesenchymal protrusion
atrioventricular septal defect ( J:189007 )
• atrioventricular canal defect




Genotype
MGI:5444486
cn2
Allelic
Composition		 Irx3tm3Hui/Irx3tm3Hui
Irx5tm3Hui/Irx5tm3Hui
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Irx3tm3Hui mutation (0 available); any Irx3 mutation (25 available)
Irx5tm3Hui mutation (0 available); any Irx5 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:189007 )
N
• no defects in heart morphology are detected




Genotype
MGI:5444490
cn3
Allelic
Composition		 Irx3tm3Hui/Irx3tm3Hui
Irx5tm3Hui/Irx5tm3Hui
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irx3tm3Hui mutation (0 available); any Irx3 mutation (25 available)
Irx5tm3Hui mutation (0 available); any Irx5 mutation (31 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal cardiac outflow tract development ( J:189007 )
• phenocopies abnormalities seen in germ line double null mice
atrial septal defect ( J:189007 )
• appears to be due to a defect in the fusion between the atrioventricular endocardial cushions and the dorsal mesenchymal protrusion
atrioventricular septal defect ( J:189007 )
• atrioventricular canal defect




Genotype
MGI:5444495
cn4
Allelic
Composition		 Irx3tm3Hui/Irx3tm3Hui
Irx5tm3Hui/Irx5tm3Hui
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (39 available)
Irx3tm3Hui mutation (0 available); any Irx3 mutation (25 available)
Irx5tm3Hui mutation (0 available); any Irx5 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
prolonged PR interval ( J:189007 )
• in tamoxifen treated mice
prolonged QRS complex duration ( J:189007 )
• in tamoxifen treated mice




Genotype
MGI:5444489
cn5
Allelic
Composition		 Irx3tm3Hui/Irx3tm3Hui
Irx5tm3Hui/Irx5tm3Hui
Tg(Nkx2-5-cre)9Eno/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irx3tm3Hui mutation (0 available); any Irx3 mutation (25 available)
Irx5tm3Hui mutation (0 available); any Irx5 mutation (31 available)
Tg(Nkx2-5-cre)9Eno mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:189007 )
N
• no defects in heart morphology are detected




Genotype
MGI:5444487
cn6
Allelic
Composition		 Irx3tm3Hui/Irx3tm3Hui
Irx5tm3Hui/Irx5tm3Hui
Tg(Mef2c-cre)#Blk/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irx3tm3Hui mutation (0 available); any Irx3 mutation (25 available)
Irx5tm3Hui mutation (0 available); any Irx5 mutation (31 available)
Tg(Mef2c-cre)#Blk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal cardiac outflow tract development ( J:189007 )
• recapitulates outflow tract abnormalities seen in germ line double null mice




Genotype
MGI:5444485
cx7
Allelic
Composition		 Irx3tm3.1Hui/Irx3tm3.1Hui
Irx5tm3Hui/Irx5tm3Hui
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irx3tm3.1Hui mutation (0 available); any Irx3 mutation (25 available)
Irx5tm3Hui mutation (0 available); any Irx5 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
abnormal cardiac outflow tract development ( J:189007 )
• improper orientation at E11.5
• misalignment at E12.5, such that the aorta is oriented toward the right ventricle
abnormal heart development ( J:189007 )
• defects in the growth of septa primum and secundum at E12.5
abnormal heart septum morphology ( J:189007 )
• defects in the growth of septa primum and secundum at E12.5
abnormal interatrial septum morphology ( J:189007 )
• absence of the dorsal mesenchymal protrusion and the septum primum at E12.5
atrioventricular septal defect ( J:189007 )
• membranous ventricular septal defect at the level of the AV canal at E12.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory