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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm12(CD2*)Rsky
targeted mutation 12, Klaus Rajewsky
MGI:5444669
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm12(CD2*)Rsky/Gt(ROSA)26Sor+
Myctm2Fwa/Myctm2Fwa
Ighg1tm1(cre)Cgn/Ighg1+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 MGI:5444672


Genotype
MGI:5444672
cn1
Allelic
Composition		 Gt(ROSA)26Sortm12(CD2*)Rsky/Gt(ROSA)26Sor+
Myctm2Fwa/Myctm2Fwa
Ighg1tm1(cre)Cgn/Ighg1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm12(CD2*)Rsky mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Ighg1tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
Myctm2Fwa mutation (2 available); any Myc mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased spleen germinal center size ( J:188564 )
• almost complete ablation of germinal centers in response to T cell dependent immunization
• the few remaining germinal center B cells have escaped cre mediated recombination

hematopoietic system
decreased spleen germinal center size ( J:188564 )
• almost complete ablation of germinal centers in response to T cell dependent immunization
• the few remaining germinal center B cells have escaped cre mediated recombination




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory