About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky
targeted mutation 13, Klaus Rajewsky
MGI:5444670
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky/Gt(ROSA)26Sor+
Myctm2Fwa/Myctm2Fwa
Ighg1tm1(cre)Cgn/Ighg1+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 MGI:5444673
cn2
Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky
Ighg1tm1(cre)Cgn/Ighg1+
involves: 129P2/OlaHsd * C57BL/6 MGI:5463978


Genotype
MGI:5444673
cn1
Allelic
Composition
Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky/Gt(ROSA)26Sor+
Myctm2Fwa/Myctm2Fwa
Ighg1tm1(cre)Cgn/Ighg1+
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (992 available)
Ighg1tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
Myctm2Fwa mutation (2 available); any Myc mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• enforced expression of human MYC rescues germinal center formation




Genotype
MGI:5463978
cn2
Allelic
Composition
Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky
Ighg1tm1(cre)Cgn/Ighg1+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (992 available)
Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (992 available)
Ighg1tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• when bone marrow is used to reconstitute Rag2 and Il2rg null mice stimulated with sheep red blood cells, median survival is 227 days

immune system
• in the Peyer's patches and spleen

neoplasm
• of germinal center B cell origin when bone marrow is used to reconstitute Rag2 and Il2rg null mice stimulated with sheep red blood cells

hematopoietic system
• in the Peyer's patches and spleen





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory