Phenotypes associated with this allele

• Allele Symbol: Tg(KRT14-Prss8)1Hum
• Allele Name: transgene insertion 1, Edith Hummler
• Allele ID: MGI:5444854
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(KRT14-Prss8)1Hum/?	involves: C57BL/6 * DBA/2	MGI:5444860

Genotype
MGI:5444860

tg1

• Allelic Composition: Tg(KRT14-Prss8)1Hum/?
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

impaired skin barrier function ( J:189278 )

♂ • increase in transepidermal water loss evident in 2 week old animals

sparse hair ( J:189278 )

♂

abnormal dermal layer morphology ( J:189278 )

♂ • more cellular

abnormal stratum corneum lipid matrix formation ( J:189278 )

♂ • elevated ceramide levels

acanthosis ( J:189278 )

♂ • as early as two days of age

♂ • associated with enhanced proliferation of keratinocytes

scaly skin ( J:189278 )

♂ • 100% penetrance

♂ • starting a few days after birth

♂ • most prominant in the ventral-abdominal region and the tail

skin lesions ( J:189278 )

♂ • evident after weaning and persistent throughout life

growth/size/body

decreased body weight ( J:189278 )

♂

homeostasis/metabolism

impaired skin barrier function ( J:189278 )

♂ • increase in transepidermal water loss evident in 2 week old animals

behavior/neurological

excessive scratching ( J:189278 )

♂ • after weaning and into adulthood