Phenotypes associated with this allele

• Allele Symbol: Tg(KRT14-Prss8)2Hum
• Allele Name: transgene insertion 2, Edith Hummler
• Allele ID: MGI:5444856
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	F2rl1^tm1Cgh/F2rl1^tm1Cgh Tg(KRT14-Prss8)2Hum/?	involves: 129S4/SvJae * C57BL/6 * DBA/2	MGI:5444869
tg2	Tg(KRT14-Prss8)2Hum/?	involves: C57BL/6 * DBA/2	MGI:5444861

Genotype
MGI:5444869

cx1

• Allelic Composition: F2rl1^tm1Cgh/F2rl1^tm1Cgh; Tg(KRT14-Prss8)2Hum/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

integument phenotype ( J:189278 )

N • absence of F2rl1 completely rescued hyperplasia, barrier dysfunction, inflammation and ichthyosis

Genotype
MGI:5444861

tg2

• Allelic Composition: Tg(KRT14-Prss8)2Hum/?
• Genetic Background: involves: C57BL/6 * DBA/2

mortality/aging

postnatal lethality, incomplete penetrance ( J:189278 )

• 55% die within the first two weeks

growth/size/body

decreased body weight ( J:189278 )

homeostasis/metabolism

impaired skin barrier function ( J:189278 )

• increase in transepidermal water loss evident in 2 week old animals

integument

impaired skin barrier function ( J:189278 )

• increase in transepidermal water loss evident in 2 week old animals

sparse hair ( J:189278 )

abnormal dermal layer morphology ( J:189278 )

• more cellular

abnormal stratum corneum lipid matrix formation ( J:189278 )

• elevated ceramide levels

acanthosis ( J:189278 )

• as early as two days of age

• associated with enhanced proliferation of keratinocytes

scaly skin ( J:189278 )

• 100% penetrance

• starting a few days after birth

• most prominant in the ventral-abdominal region and the tail

skin lesions ( J:189278 )

• evident after weaning and persistent throughout life

behavior/neurological

excessive scratching ( J:189278 )

• after weaning and into adulthood