Phenotypes associated with this allele

• Allele Symbol: Grhl3^{tm2.1(F2rl1)Cgh}
• Allele Name: targeted mutation 2.1, Shaun R Coughlin
• Allele ID: MGI:5444857
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grhl3^tm2.1(F2rl1)Cgh/Grhl3^tm2.1(F2rl1)Cgh	either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * FVB/N)	MGI:5444858
ht2	Grhl3^tm2.1(F2rl1)Cgh/Grhl3^+	either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * FVB/N)	MGI:5444859

Genotype
MGI:5444858

hm1

• Allelic Composition: Grhl3^{tm2.1(F2rl1)Cgh}/Grhl3^{tm2.1(F2rl1)Cgh}
• Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * FVB/N)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:189278 )

embryo

spina bifida ( J:189278 )

nervous system

spina bifida ( J:189278 )

Genotype
MGI:5444859

ht2

• Allelic Composition: Grhl3^{tm2.1(F2rl1)Cgh}/Grhl3⁺
• Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * FVB/N)

integument

epidermal hyperplasia ( J:189278 )

• from two weeks onward

scaly skin ( J:189278 )

• although normal at birth, mice start to display scaly skin from 2 weeks onward

• most evident on the tail

skin lesions ( J:189278 )

• with occasional lymph node swelling

behavior/neurological

excessive scratching ( J:189278 )

• in adulthood but not in young mice

• not observed in mice without skin lesions and does not preceed the appearance of lesions