All Phenotypes St3gal6<tm1.1Jxm> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	St3gal6^tm1.1Jxm/St3gal6^tm1.1Jxm	B6.Cg-St3gal6^tm1.1Jxm	MGI:5445107
cx2	St3gal4^tm1.1Jxm/St3gal4^tm1.1Jxm St3gal6^tm1.1Jxm/St3gal6^tm1.1Jxm	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5445109

Allelic Composition	St3gal6^tm1.1Jxm/St3gal6^tm1.1Jxm
Genetic Background	B6.Cg-St3gal6^tm1.1Jxm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
St3gal6^tm1.1Jxm mutation (0 available); any St3gal6 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:189086 )

N	• mice exhibit normal leukocytosis, thrombopoiesis and recruitment of monocytes

impaired leukocyte tethering or rolling ( J:189086 )

• modestly impaired P- and E-selectin-dependent rolling impaired rolling under dynamic flow conditions

• impaired P-selectin-dependent rolling during inflammation in vivo

• however, in vivo inflammation induced E-selectin-dependent rolling is normal

impaired neutrophil recruitment ( J:189086 )

• moderately impaired neutrophil recruitment into inflamed peritoneum after injection of thioglycollate

cellular

impaired leukocyte tethering or rolling ( J:189086 )

• modestly impaired P- and E-selectin-dependent rolling impaired rolling under dynamic flow conditions

• impaired P-selectin-dependent rolling during inflammation in vivo

• however, in vivo inflammation induced E-selectin-dependent rolling is normal

hematopoietic system

impaired leukocyte tethering or rolling ( J:189086 )

• modestly impaired P- and E-selectin-dependent rolling impaired rolling under dynamic flow conditions

• impaired P-selectin-dependent rolling during inflammation in vivo

• however, in vivo inflammation induced E-selectin-dependent rolling is normal

impaired neutrophil recruitment ( J:189086 )

• moderately impaired neutrophil recruitment into inflamed peritoneum after injection of thioglycollate

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal leukocyte migration ( J:189086 )

• impaired lymphocyte homing into lymph nodes and Peyer's patches

impaired leukocyte tethering or rolling ( J:189086 )

• impaired P- and E-selectin-dependent rolling under dynamic flow conditions, more so than in St3gal6^tm1.1Jxm homozygotes

• impaired P- and E-selectin-dependent rolling during inflammation in vivo

decreased lymphocyte cell number ( J:189086 )

• reduced lymphocytes in the abdominal, celiac, mesenteric and inguinal lymph nodes and Peyer's patch

• however, the number of lymphocytes in the spleen, thymus and bone marrow is normal

increased leukocyte cell number ( J:189086 )

increased neutrophil cell number ( J:189086 )

impaired neutrophil recruitment ( J:189086 )

• impaired neutrophil recruitment into inflamed peritoneum after injection of thioglycollate, more so than in St3gal6^tm1.1Jxm homozygotes

hematopoietic system

hematopoietic system phenotype ( J:189086 )

N	• mice exhibit normal numbers of red blood cells and recruitment of monocytes

abnormal leukocyte migration ( J:189086 )

• impaired lymphocyte homing into lymph nodes and Peyer's patches

impaired leukocyte tethering or rolling ( J:189086 )

• impaired P- and E-selectin-dependent rolling under dynamic flow conditions, more so than in St3gal6^tm1.1Jxm homozygotes

• impaired P- and E-selectin-dependent rolling during inflammation in vivo

thrombocytopenia ( J:189086 )

• more so than in St3gal4^tm1.1Jxm homozygotes

increased mean platelet volume ( J:189086 )

• more so than in St3gal4^tm1.1Jxm homozygotes

decreased lymphocyte cell number ( J:189086 )

• reduced lymphocytes in the abdominal, celiac, mesenteric and inguinal lymph nodes and Peyer's patch

• however, the number of lymphocytes in the spleen, thymus and bone marrow is normal

increased leukocyte cell number ( J:189086 )

increased neutrophil cell number ( J:189086 )

impaired neutrophil recruitment ( J:189086 )

• impaired neutrophil recruitment into inflamed peritoneum after injection of thioglycollate, more so than in St3gal6^tm1.1Jxm homozygotes

cellular

abnormal leukocyte migration ( J:189086 )

• impaired lymphocyte homing into lymph nodes and Peyer's patches

impaired leukocyte tethering or rolling ( J:189086 )

• impaired P- and E-selectin-dependent rolling under dynamic flow conditions, more so than in St3gal6^tm1.1Jxm homozygotes

• impaired P- and E-selectin-dependent rolling during inflammation in vivo

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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