All Phenotypes Fnip1<tm1.1Baba> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fnip1^tm1.1Baba
targeted mutation 1.1, Masaya Baba
MGI:5445115

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fnip1^tm1.1Baba/Fnip1^tm1.1Baba Tg(Ckmm-cre)5Khn/0	involves: C57BL/6 * FVB	MGI:5897113
cn2	Fnip1^tm1.1Baba/Fnip1^tm1.1Baba Tg(Cdh16-cre)91Igr/0	involves: C57BL/6 * ICR	MGI:5897110
cn3	Fnip1^tm1.1Baba/Fnip1^tm1.1Baba Fnip2^tm1.1Lss/Fnip2^tm1.1Lss Tg(Cdh16-cre)91Igr/0	involves: C57BL/6 * ICR	MGI:5897114
cn4	Flcn^tm1Baba/Flcn^tm1Baba Fnip1^tm1.1Baba/Fnip1^tm1.1Baba Fnip2^tm1.1Lss/Fnip2^tm1.1Lss Tg(Cdh16-cre)91Igr/0	involves: C57BL/6 * ICR	MGI:5897115

Allelic Composition	Fnip1^tm1.1Baba/Fnip1^tm1.1Baba Tg(Ckmm-cre)5Khn/0
Genetic Background	involves: C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1^tm1.1Baba mutation (0 available); any Fnip1 mutation (60 available)
Tg(Ckmm-cre)5Khn mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle morphology ( J:220672 )

• red colored

abnormal muscle physiology ( J:220672 )

• increased mitochondrial biogenesis in muscle

cardiovascular system

cardiac hypertrophy ( J:220672 )

cellular

abnormal mitochondrial physiology ( J:220672 )

• increased mitochondrial biogenesis in muscle

growth/size/body

cardiac hypertrophy ( J:220672 )

Allelic Composition	Fnip1^tm1.1Baba/Fnip1^tm1.1Baba Tg(Cdh16-cre)91Igr/0
Genetic Background	involves: C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1^tm1.1Baba mutation (0 available); any Fnip1 mutation (60 available)
Tg(Cdh16-cre)91Igr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

kidney cyst ( J:220672 )

• occasional tiny cysts

growth/size/body

kidney cyst ( J:220672 )

• occasional tiny cysts

Allelic Composition	Fnip1^tm1.1Baba/Fnip1^tm1.1Baba Fnip2^tm1.1Lss/Fnip2^tm1.1Lss Tg(Cdh16-cre)91Igr/0
Genetic Background	involves: C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1^tm1.1Baba mutation (0 available); any Fnip1 mutation (60 available)
Fnip2^tm1.1Lss mutation (0 available); any Fnip2 mutation (60 available)
Tg(Cdh16-cre)91Igr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:220672 )

• survival time is about 3 weeks

renal/urinary system

polycystic kidney ( J:220672 )

enlarged kidney ( J:220672 )

cellular

abnormal mitochondrial physiology ( J:220672 )

• increased respiratory capacity and mitochondrial surface area indicating increased mitochondrial biogenesis

growth/size/body

polycystic kidney ( J:220672 )

enlarged kidney ( J:220672 )

Allelic Composition	Flcn^tm1Baba/Flcn^tm1Baba Fnip1^tm1.1Baba/Fnip1^tm1.1Baba Fnip2^tm1.1Lss/Fnip2^tm1.1Lss Tg(Cdh16-cre)91Igr/0
Genetic Background	involves: C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flcn^tm1Baba mutation (0 available); any Flcn mutation (42 available)
Fnip1^tm1.1Baba mutation (0 available); any Fnip1 mutation (60 available)
Fnip2^tm1.1Lss mutation (0 available); any Fnip2 mutation (60 available)
Tg(Cdh16-cre)91Igr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

polycystic kidney ( J:220672 )

• no increase in severity of cystic phenotype compared to mutant mice wild-type for Flcn

enlarged kidney ( J:220672 )

• no increase in severity of phenotype compared to mutant mice wild-type for Flcn

growth/size/body

polycystic kidney ( J:220672 )

• no increase in severity of cystic phenotype compared to mutant mice wild-type for Flcn

enlarged kidney ( J:220672 )

• no increase in severity of phenotype compared to mutant mice wild-type for Flcn

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