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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fnip1tm1.2Baba
targeted mutation 1.2, Masaya Baba
MGI:5445116
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fnip1tm1.2Baba/Fnip1tm1.2Baba involves: C57BL/6 MGI:5897121
hm2
 		Fnip1tm1.2Baba/Fnip1tm1.2Baba involves: C57BL/6 * C57BL/6J * FVB/N * SJL MGI:5445162
cx3
 		Fnip1tm1.2Baba/Fnip1tm1.2Baba
Ightm2Cgn/Ightm2Cgn 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL MGI:5445167
cx4
 		Fnip1tm1.2Baba/Fnip1+
Fnip2tm1.2Lss/Fnip2tm1.2Lss 		involves: C57BL/6 MGI:5897118
cx5
 		Fnip1tm1.2Baba/Fnip1tm1.2Baba
Tg(IghelMD4)4Ccg/0 		involves: C57BL/6 * C57BL/6J * FVB/N * SJL MGI:5445165
cx6
 		Fnip1tm1.2Baba/Fnip1tm1.2Baba
Tg(BCL2)22Wehi/0 		involves: C57BL/6 * FVB/N * SJL MGI:5445170


Genotype
MGI:5897121
hm1
Allelic
Composition		 Fnip1tm1.2Baba/Fnip1tm1.2Baba
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1tm1.2Baba mutation (0 available); any Fnip1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:220672 )
• median survival is 292 days




Genotype
MGI:5445162
hm2
Allelic
Composition		 Fnip1tm1.2Baba/Fnip1tm1.2Baba
Genetic
Background		 involves: C57BL/6 * C57BL/6J * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1tm1.2Baba mutation (0 available); any Fnip1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased pro-B cell number ( J:189078 )
• 2- to 3-fold
• accumulation of fraction C and C'
arrested B cell differentiation ( J:189078 )
• cell intrinsic block in B cell development at the pro-B cell fractions C-C'
• not rescued by rapamycin treatment or pre-recombined B cell receptor
decreased B cell number ( J:189078 )
• severe, nearly complete absence of conventional CD19+ cells
absent B cells ( J:189078 )
• absence of peripheral B cells

renal/urinary system
renal/urinary system phenotype ( J:189078 )
N
• mice do not develop kidney cysts or renal failure

cellular

hematopoietic system
increased pro-B cell number ( J:189078 )
• 2- to 3-fold
• accumulation of fraction C and C'
arrested B cell differentiation ( J:189078 )
• cell intrinsic block in B cell development at the pro-B cell fractions C-C'
• not rescued by rapamycin treatment or pre-recombined B cell receptor
decreased B cell number ( J:189078 )
• severe, nearly complete absence of conventional CD19+ cells
absent B cells ( J:189078 )
• absence of peripheral B cells




Genotype
MGI:5445167
cx3
Allelic
Composition		 Fnip1tm1.2Baba/Fnip1tm1.2Baba
Ightm2Cgn/Ightm2Cgn
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1tm1.2Baba mutation (0 available); any Fnip1 mutation (60 available)
Ightm2Cgn mutation (1 available); any Igh mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
absent B cells ( J:189078 )
• absence of peripheral B cells

immune system
absent B cells ( J:189078 )
• absence of peripheral B cells




Genotype
MGI:5897118
cx4
Allelic
Composition		 Fnip1tm1.2Baba/Fnip1+
Fnip2tm1.2Lss/Fnip2tm1.2Lss
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1tm1.2Baba mutation (0 available); any Fnip1 mutation (60 available)
Fnip2tm1.2Lss mutation (0 available); any Fnip2 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased kidney tumor incidence ( J:220672 )
• develop kidney cancer
• develop a variety of lesions with hybrid oncocytic tumors being most common

renal/urinary system
increased kidney tumor incidence ( J:220672 )
• develop kidney cancer
• develop a variety of lesions with hybrid oncocytic tumors being most common

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Birt-Hogg-Dube syndrome DOID:0050676 OMIM:135150
 J:220672




Genotype
MGI:5445165
cx5
Allelic
Composition		 Fnip1tm1.2Baba/Fnip1tm1.2Baba
Tg(IghelMD4)4Ccg/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1tm1.2Baba mutation (0 available); any Fnip1 mutation (60 available)
Tg(IghelMD4)4Ccg mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased immature B cell number ( J:189078 )
• in the bone marrow compared with Fnip1tm1.2Tes or Fnip1Gt(RRM154)Byg homozygotes
absent B cells ( J:189078 )
• absence of peripheral B cells

immune system
increased immature B cell number ( J:189078 )
• in the bone marrow compared with Fnip1tm1.2Tes or Fnip1Gt(RRM154)Byg homozygotes
absent B cells ( J:189078 )
• absence of peripheral B cells




Genotype
MGI:5445170
cx6
Allelic
Composition		 Fnip1tm1.2Baba/Fnip1tm1.2Baba
Tg(BCL2)22Wehi/0
Genetic
Background		 involves: C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1tm1.2Baba mutation (0 available); any Fnip1 mutation (60 available)
Tg(BCL2)22Wehi mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased B cell number ( J:189078 )
• in the bone marrow compared with Fnip1tm1.2Tes or Fnip1Gt(RRM154)Byg homozygotes

immune system
increased B cell number ( J:189078 )
• in the bone marrow compared with Fnip1tm1.2Tes or Fnip1Gt(RRM154)Byg homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory