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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nlrc5tm1Itl
targeted mutation 1, inGenious Targeting Laboratory
MGI:5445207
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nlrc5tm1Itl/Nlrc5tm1Itl C57BL/6-Nlrc5tm1Itl MGI:5445236


Genotype
MGI:5445236
hm1
Allelic
Composition		 Nlrc5tm1Itl/Nlrc5tm1Itl
Genetic
Background		 C57BL/6-Nlrc5tm1Itl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc5tm1Itl mutation (0 available); any Nlrc5 mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:188857 )
N
• mice exhibit normal cytokine production in response to pathogen- associated molecular patterns (PAMPs) and viruses
decreased interferon-beta secretion ( J:188857 )
• in bone marrow-derived macrophage stimulated with herpes simplex virus
decreased interleukin-6 secretion ( J:188857 )
• in bone marrow-derived macrophage stimulated with CpG




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory