Phenotypes associated with this allele

• Allele Symbol: Klra15^tm1.1Apma
• Allele Name: targeted mutation 1.1, Andrew P Makrigiannis
• Allele ID: MGI:5445244
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klra15^tm1.1Apma/Klra15^tm1.1Apma	B6.129-Klra15^tm1.1Apma	MGI:5445270

Genotype
MGI:5445270

hm1

• Allelic Composition: Klra15^tm1.1Apma/Klra15^tm1.1Apma
• Genetic Background: B6.129-Klra15^tm1.1Apma

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired natural killer cell mediated cytotoxicity ( J:189106 )

• in vivo and in vitro killing of MHC-I-deficient hematopoietic and tumor cells

• however, self-specific Klra transgene restores MHC-I immunosurveillance and activation restores MHC-I-deficient tumor cell killing

• however, NK cells display normal cytokine and degranulation responses

hematopoietic system

impaired natural killer cell mediated cytotoxicity ( J:189106 )

• in vivo and in vitro killing of MHC-I-deficient hematopoietic and tumor cells

• however, self-specific Klra transgene restores MHC-I immunosurveillance and activation restores MHC-I-deficient tumor cell killing

• however, NK cells display normal cytokine and degranulation responses