Phenotypes associated with this allele

• Allele Symbol: Thbd^tm1.1Hlwu
• Allele Name: targeted mutation 1.1, Hua-Lin Wu
• Allele ID: MGI:5445362
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Thbd^tm1.1Hlwu/Thbd^tm1.1Hlwu Lyz2^tm1(cre)Ifo/Lyz2^+	B6.129-Thbd^tm1.1Hlwu Lyz2^tm1(cre)Ifo	MGI:5445365

Genotype
MGI:5445365

cn1

• Allelic Composition: Thbd^tm1.1Hlwu/Thbd^tm1.1Hlwu; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: B6.129-Thbd^tm1.1Hlwu Lyz2^tm1(cre)Ifo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:188879 )

• in mice infected with K. pneumonia

decreased susceptibility to induced morbidity/mortality ( J:188879 )

• following cecal ligation and puncture

immune system

decreased circulating interleukin-6 level ( J:188879 )

• in mice infected with K. pneumonia or following cecal ligation and puncture

• however, response to S. aureus is normal

decreased circulating tumor necrosis factor level ( J:188879 )

• in mice infected with K. pneumonia or following cecal ligation and puncture

decreased tumor necrosis factor secretion ( J:188879 )

• in peritoneal macrophages from mice stimulated with LPS or K. pneumonia

• however, response to LTA and S. aureus is normal

decreased susceptibility to bacterial infection ( J:188879 )

• mice infected with K. pneumonia exhibit improved survival, decreased circulating levels of IL6 and TNFalpha, decreased bacterial dissemination and increased neutrophil infiltration compared with control mice

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:188879 )

• in mice infected with K. pneumonia

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:188879 )

• in mice infected with K. pneumonia or following cecal ligation and puncture

• however, response to S. aureus is normal

decreased circulating tumor necrosis factor level ( J:188879 )

• in mice infected with K. pneumonia or following cecal ligation and puncture

decreased susceptibility to injury ( J:188879 )

• following cecal ligation and puncture, mice exhibit improved survival, decreased circulating levels of IL6 and TNFalpha, decreased bacterial dissemination and increased neutrophil infiltration compared with control mice