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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hcfc2fkls
feckless
MGI:5445585
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hcfc2fkls/Hcfc2fkls C57BL/6J-Hcfc2fkls MGI:5445629
hm2
 		Hcfc2fkls/Hcfc2fkls involves: C57BL/6J MGI:6108115
ht3
 		Hcfc2fkls/Hcfc2+ involves: C57BL/6J MGI:6108114
ht4
 		Hcfc2fkls/Hcfc2min involves: C57BL/6J MGI:6108116
ht5
 		Hcfc2fkls/Hcfc2sca involves: C57BL/6J MGI:6108117


Genotype
MGI:5445629
hm1
Allelic
Composition		 Hcfc2fkls/Hcfc2fkls
Genetic
Background		 C57BL/6J-Hcfc2fkls
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcfc2fkls mutation (1 available); any Hcfc2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal innate immunity ( J:94077 )
• homozygous mutants exhibit no response to viral dsRNA.




Genotype
MGI:6108115
hm2
Allelic
Composition		 Hcfc2fkls/Hcfc2fkls
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcfc2fkls mutation (1 available); any Hcfc2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:251008 )
• all HSV1-infected mice die unlike wild-type mice
increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:251008 )
• all influenza A--infected mice die unlike wild-type mice

immune system
decreased interferon-beta secretion ( J:251008 )
• in peritoneal macrophages stimulated with poly(I:C)
decreased tumor necrosis factor secretion ( J:251008 )
• from macrophages of mice stimulated with poly(I:C)
• however, TNF production in response to Pam3CSK4, MALP-1, LPS, flagellin, R848 and CpG-ODN 1668 is normal
increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:251008 )
• all influenza A--infected mice die unlike wild-type mice
increased susceptibility to Herpesvirales infection ( J:251008 )
• HSV1-infected mice exhibit reduced circulating IFNa and b and die unlike wild-type mice
increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:251008 )
• all HSV1-infected mice die unlike wild-type mice

homeostasis/metabolism




Genotype
MGI:6108114
ht3
Allelic
Composition		 Hcfc2fkls/Hcfc2+
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcfc2fkls mutation (1 available); any Hcfc2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interferon-beta secretion ( J:251008 )
• in peritoneal macrophages stimulated with poly(I:C) despite normal poly(I:C) uptake
decreased tumor necrosis factor secretion ( J:251008 )
• moderate from macrophages of mice stimulated with poly(I:C)
• however, TNF production in response to Pam3CSK4, MALP-1, LPS, flagellin, R848 and CpG-ODN 1668 is normal




Genotype
MGI:6108116
ht4
Allelic
Composition		 Hcfc2fkls/Hcfc2min
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcfc2fkls mutation (1 available); any Hcfc2 mutation (33 available)
Hcfc2min mutation (1 available); any Hcfc2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased tumor necrosis factor secretion ( J:251008 )
• from macrophages of mice stimulated with poly(I:C)




Genotype
MGI:6108117
ht5
Allelic
Composition		 Hcfc2fkls/Hcfc2sca
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcfc2fkls mutation (1 available); any Hcfc2 mutation (33 available)
Hcfc2sca mutation (1 available); any Hcfc2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased tumor necrosis factor secretion ( J:251008 )
• from macrophages of mice stimulated with poly(I:C)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory