All Phenotypes Insl5<tm1Imad> MGI Mouse

cellular

asthenozoospermia ( J:189146 )

reproductive system

reproductive system phenotype ( J:189146 )

N	• male mice exhibit normal male germ cell development and spermatozoa migration in the genital tract of females • female mice exhibit normal numbers of oocytes

asthenozoospermia ( J:189146 )

abnormal estrous cycle ( J:189146 )

• irregular

female infertility ( J:189146 )

• Background Sensitivity: 7 of 12 breeding pairs unlike mice on a mixed background

reduced female fertility ( J:189146 )

• Background Sensitivity: 5 of 12 breeding pairs unlike mice on a mixed background

decreased litter size ( J:189146 )

• Background Sensitivity: in 5 of 12 breeding pairs unlike mice on a mixed background

male infertility ( J:189146 )

• Background Sensitivity: 7 of 12 breeding pairs unlike mice on a mixed background

reduced male fertility ( J:189146 )

• Background Sensitivity: 5 of 12 breeding pairs unlike mice on a mixed background

homeostasis/metabolism

hyperglycemia ( J:189146 )

• in fasted mice at 3 through 12 months

• during intraperitoneal glucose tolerance test challenge at 3 and 9 months

• at 9 months prior to and following glucose challenge

impaired glucose tolerance ( J:189146 )

• at 9 months

renal/urinary system

polyuria ( J:189146 )

• at 9 months

endocrine/exocrine glands

small pancreatic islets ( J:189146 )

• 1.6-fold smaller

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24