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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Abcb10tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:5445808
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Abcb10tm1Lex/Abcb10tm1Lex involves: 129S/SvEvBrd * C57BL/6 MGI:5445889
ht2
 		Abcb10tm1Lex/Abcb10+ involves: 129S/SvEvBrd * C57BL/6 MGI:5445890


Genotype
MGI:5445889
hm1
Allelic
Composition		 Abcb10tm1Lex/Abcb10tm1Lex
Genetic
Background		 involves: 129S/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcb10tm1Lex mutation (1 available); any Abcb10 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5445890
ht2
Allelic
Composition		 Abcb10tm1Lex/Abcb10+
Genetic
Background		 involves: 129S/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcb10tm1Lex mutation (1 available); any Abcb10 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:189396 )
N
• mice exhibit normal hemodynamic and mitochondrial function under basal conditions
increased response of heart to induced stress ( J:189396 )
• after ischemia and reperfusion, mice exhibit reduced recovery, increased diastolic pressure, small decrease in systolic pressure, decrease in mitochondria respiration, and increased oxidative stress compared with wild-type mice
• however, EUK-207 (a superoxide dismutase/catalase mimetic) rescues contractile and mitochondrial function after ischemia and reperfusion
decreased systemic arterial systolic blood pressure ( J:189396 )
• small after ischemia and reperfusion
increased systemic arterial diastolic blood pressure ( J:189396 )
• after ischemia and reperfusion

cellular
abnormal mitochondrial physiology ( J:189396 )
• decreased mitochondrial respiration after ischemia and reperfusion
• however, EUK-207 (a superoxide dismutase/catalase mimetic) rescues mitochondrial function after ischemia and reperfusion
oxidative stress ( J:189396 )
• after ischemia and reperfusion

homeostasis/metabolism
increased response of heart to induced stress ( J:189396 )
• after ischemia and reperfusion, mice exhibit reduced recovery, increased diastolic pressure, small decrease in systolic pressure, decrease in mitochondria respiration, and increased oxidative stress compared with wild-type mice
• however, EUK-207 (a superoxide dismutase/catalase mimetic) rescues contractile and mitochondrial function after ischemia and reperfusion




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory