Phenotypes associated with this allele

• Allele Symbol: Mrps25^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5445931
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mrps25^tm1.1(KOMP)Vlcg/Mrps25^tm1.1(KOMP)Vlcg	C57BL/6N-Mrps25^tm1.1(KOMP)Vlcg/J	MGI:5631318
hm2	Mrps25^tm1.1(KOMP)Vlcg/Mrps25^tm1.1(KOMP)Vlcg	C57BL/6N-Mrps25^tm1.1(KOMP)Vlcg/JMmucd	MGI:6377012
ht3	Mrps25^tm1.1(KOMP)Vlcg/Mrps25^+	C57BL/6N-Mrps25^tm1.1(KOMP)Vlcg/J	MGI:5631317

Genotype
MGI:5631318

hm1

• Allelic Composition: Mrps25^{tm1.1(KOMP)Vlcg}/Mrps25^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Mrps25^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 12105B-B6

Data Sources

IMPC Data for Mrps25

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:6377012

hm2

• Allelic Composition: Mrps25^{tm1.1(KOMP)Vlcg}/Mrps25^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Mrps25^{tm1.1(KOMP)Vlcg}/JMmucd
• Cell Lines: 12105B-B6

Mrps25^{tm1.1(KOMP)Vlcg}/Mrps25^{tm1.1(KOMP)Vlcg} mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos exhibit embryonic growth retardation, failure of primitive streak formation, and disorganized extraembryonic tissue.

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )

• homozygous embryos are recovered at E7.5 (18% versus 25%, n=28) and arrest prior to gastrulation; no homozygous embryos are recovered at E9.5

embryo

failure to gastrulate ( J:290315 )

embryonic growth arrest ( J:279207 )

• embryos arrest prior to gastrulation

embryonic growth retardation ( J:279207 )

• at E7.5, embryos are developmentally delayed (~E6.0 size)

• however, many phospho-histoneH3 (PH3)-positive dividing cells are present

failure of primitive streak formation ( J:279207 )

• no Brachyury (T)-positive cells are observed at E7.5, suggesting failure to initiate primitive streak formation

disorganized extraembryonic tissue ( J:279207 )

• at E7.5, extraembryonic tissues are poorly organized

growth/size/body

embryonic growth retardation ( J:279207 )

• at E7.5, embryos are developmentally delayed (~E6.0 size)

• however, many phospho-histoneH3 (PH3)-positive dividing cells are present

Genotype
MGI:5631317

ht3

• Allelic Composition: Mrps25^{tm1.1(KOMP)Vlcg}/Mrps25⁺
• Genetic Background: C57BL/6N-Mrps25^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 12105B-B6

Data Sources

IMPC Data for Mrps25

cardiovascular system

increased heart weight ( J:211773 )

♂

IMPC - JAX

growth/size/body

increased heart weight ( J:211773 )

♂

IMPC - JAX

homeostasis/metabolism

decreased circulating glucose level ( J:211773 )

IMPC - JAX

decreased circulating calcium level ( J:211773 )

♀

IMPC - JAX

increased circulating sodium level ( J:211773 )

♂

IMPC - JAX