Phenotypes associated with this allele

• Allele Symbol: Rasa1^tm1Wid
• Allele Name: targeted mutation 1, Christian Widmann
• Allele ID: MGI:5446031
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rasa1^tm1Wid/Rasa1^tm1Wid	involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6N	MGI:5446052

Genotype
MGI:5446052

hm1

• Allelic Composition: Rasa1^tm1Wid/Rasa1^tm1Wid
• Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased sensitivity to induced cell death ( J:189241 )

• embryonic cells do not survive long-term trypsin digest unlike wild-type cells

• in the cardiomyocytes of mice treated with doxorubicin

increased cellular sensitivity to ultraviolet irradiation ( J:189241 )

• mice exposed to UV-B radiation exhibit increased sunburn cells in the epidermis compared with wild-type mice

increased cardiomyocyte apoptosis ( J:189241 )

• in mice treated with doxorubicin

increased enterocyte apoptosis ( J:189241 )

• greater in DSS-treated mice

cardiovascular system

abnormal cardiovascular system physiology ( J:189241 )

• more impaired cardiac function (reduced end-systolic elastance) in mice treated with doxorubicin

digestive/alimentary system

increased enterocyte apoptosis ( J:189241 )

• greater in DSS-treated mice

decreased colon length ( J:189241 )

• greater decrease of colon length in DSS-treated mice

increased susceptibility to induced colitis ( J:189241 )

• DSS-treated mice exhibit increased epithelial cell apoptosis, decreased colon length and increased clinical score compared with wild-type mice

immune system

increased susceptibility to induced colitis ( J:189241 )

• DSS-treated mice exhibit increased epithelial cell apoptosis, decreased colon length and increased clinical score compared with wild-type mice

muscle

increased cardiomyocyte apoptosis ( J:189241 )

• in mice treated with doxorubicin