Phenotypes associated with this allele

• Allele Symbol: Dnmt3a^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5446396
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnmt3a^tm1b(KOMP)Wtsi/Dnmt3a^tm1b(KOMP)Wtsi	C57BL/6N-Dnmt3a^tm1b(KOMP)Wtsi/J	MGI:5631069
ht2	Dnmt3a^tm1b(KOMP)Wtsi/Dnmt3a^+	C57BL/6N-Dnmt3a^tm1b(KOMP)Wtsi/J	MGI:5631068

Genotype
MGI:5631069

hm1

• Allelic Composition: Dnmt3a^{tm1b(KOMP)Wtsi}/Dnmt3a^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Dnmt3a^{tm1b(KOMP)Wtsi}/J
• Cell Lines: EPD0332_1_A05

Data Sources

IMPC Data for Dnmt3a

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal embryo size ( J:211773 )

♀

IMPC - JAX

growth/size/body

abnormal embryo size ( J:211773 )

♀

IMPC - JAX

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:5631068

ht2

• Allelic Composition: Dnmt3a^{tm1b(KOMP)Wtsi}/Dnmt3a⁺
• Genetic Background: C57BL/6N-Dnmt3a^{tm1b(KOMP)Wtsi}/J
• Cell Lines: EPD0332_1_A05

Data Sources

IMPC Data for Dnmt3a

adipose tissue

increased total body fat amount ( J:211773 )

♀

IMPC - JAX

behavior/neurological

decreased exploration in new environment ( J:211773 )

♂

IMPC - JAX

convulsive seizures ( J:211773 )

♀

IMPC - JAX

growth/size/body

decreased lean body mass ( J:211773 )

♀

IMPC - JAX

homeostasis/metabolism

decreased circulating glucose level ( J:211773 )

♂

IMPC - JAX

decreased circulating cholesterol level ( J:211773 )

♂

IMPC - JAX

decreased circulating HDL cholesterol level ( J:211773 )

♂

IMPC - JAX

nervous system

convulsive seizures ( J:211773 )

♀

IMPC - JAX

skeleton

abnormal bone structure ( J:211773 )

♀

IMPC - JAX