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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tbk1tm1Arte
targeted mutation 1, TaconicArtemis
MGI:5446427
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tbk1tm1Arte/Tbk1tm1Arte
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129/SvEv * 129P2/OlaHsd * C57BL/6 MGI:5446428
cn2
 		Tbk1tm1Arte/Tbk1tm1Arte
Map3k14tm1Rds/Map3k14tm1Rds
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129/SvEv * 129P2/OlaHsd * C57BL/6 MGI:5446431


Genotype
MGI:5446428
cn1
Allelic
Composition		 Tbk1tm1Arte/Tbk1tm1Arte
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129/SvEv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Tbk1tm1Arte mutation (0 available); any Tbk1 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased mature B cell number ( J:188560 )
• much greater frequency of IgA+ B cells in mesenteric lymph nodes and Peyer's patches compared to age matched controls
• significantly greater frequency and number of IgA+ B cells in the spleen in young mice immunized with a T cell dependent antigen
abnormal B cell physiology ( J:188560 )
• moderate increase in NKKB activation following induction
abnormal class switch recombination ( J:188560 )
• expression analysis indicates a defect in the negative regulation of class switching to IgA
increased IgA level ( J:188560 )
• production of antigen specific IgA in immunized mice is enhanced compared to similarly treated controls
• starting at 12 weeks of age serum IgA levels are increased in unimmunized mice compared to aged match controls
increased IgM level ( J:188560 )
• production of antigen specific IgM in immunized mice is moderately enhanced compared to similarly treated controls
increased anti-nuclear antigen antibody level ( J:188560 )
• higher serum titers of the autoantibody antinuclear antigen at 8 months of age

renal/urinary system
increased urine protein level ( J:188560 )
• at 8 months of age
abnormal kidney physiology ( J:188560 )
• prominent deposition of antibodies in the kidney glomeruli at 8 months of age a sign of nephropathy

homeostasis/metabolism
increased urine protein level ( J:188560 )
• at 8 months of age

hematopoietic system
increased mature B cell number ( J:188560 )
• much greater frequency of IgA+ B cells in mesenteric lymph nodes and Peyer's patches compared to age matched controls
• significantly greater frequency and number of IgA+ B cells in the spleen in young mice immunized with a T cell dependent antigen
abnormal B cell physiology ( J:188560 )
• moderate increase in NKKB activation following induction
abnormal class switch recombination ( J:188560 )
• expression analysis indicates a defect in the negative regulation of class switching to IgA
increased IgA level ( J:188560 )
• production of antigen specific IgA in immunized mice is enhanced compared to similarly treated controls
• starting at 12 weeks of age serum IgA levels are increased in unimmunized mice compared to aged match controls
increased IgM level ( J:188560 )
• production of antigen specific IgM in immunized mice is moderately enhanced compared to similarly treated controls




Genotype
MGI:5446431
cn2
Allelic
Composition		 Tbk1tm1Arte/Tbk1tm1Arte
Map3k14tm1Rds/Map3k14tm1Rds
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129/SvEv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Map3k14tm1Rds mutation (1 available); any Map3k14 mutation (41 available)
Tbk1tm1Arte mutation (0 available); any Tbk1 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:188560 )
• no significant increase in the production of IgA+ compared to mice homozygous for Map3k14tm1Rds alone
abnormal immunoglobulin level ( J:188560 )
• unlike mutant mice wild-type for Map3k14 the serum titer of IgA is not elevated

hematopoietic system
abnormal B cell differentiation ( J:188560 )
• no significant increase in the production of IgA+ compared to mice homozygous for Map3k14tm1Rds alone
abnormal immunoglobulin level ( J:188560 )
• unlike mutant mice wild-type for Map3k14 the serum titer of IgA is not elevated




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory