Phenotypes associated with this allele

• Allele Symbol: Yap1^tm1.1Eno
• Allele Name: targeted mutation 1.1, Eric N Olson
• Allele ID: MGI:5446483
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Yap1^tm1.1Eno/Yap1^tm1.1Eno Nkx2-5^tm1(cre)Rjs/Nkx2-5^+	involves: 129S/SvEv	MGI:5446510
cn2	Wwtr1^tm1.1Eno/Wwtr1^tm1.1Eno Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0	involves: 129S/SvEv * FVB/N	MGI:5544298
cn3	Wwtr1^tm1.1Eno/Wwtr1^+ Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0	involves: 129S/SvEv * FVB/N	MGI:5544297
cn4	Wwtr1^tm1.1Eno/Wwtr1^tm1.1Eno Yap1^tm1.1Eno/Yap1^+ Tg(Myh6-cre)2182Mds/0	involves: 129S/SvEv * FVB/N	MGI:5544296
cn5	Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0	involves: 129S/SvEv * FVB/N	MGI:5544295

Genotype
MGI:5446510

cn1

• Allelic Composition: Yap1^tm1.1Eno/Yap1^tm1.1Eno; Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:189577 )

• embryos are dead at E10.5

cardiovascular system

abnormal myocardium layer morphology ( J:189577 )

thin myocardium ( J:189577 )

• abnormally thin myocardium

• ventricular myocyte number is significantly reduced

• cardiac looping and chamber formation are normal

decreased heart rate ( J:189577 )

• slower heart beat at E9.5

• mice are normal at E8.5

muscle

abnormal myocardium layer morphology ( J:189577 )

thin myocardium ( J:189577 )

• abnormally thin myocardium

• ventricular myocyte number is significantly reduced

• cardiac looping and chamber formation are normal

Genotype
MGI:5544298

cn2

• Allelic Composition: Wwtr1^tm1.1Eno/Wwtr1^tm1.1Eno; Yap1^tm1.1Eno/Yap1^tm1.1Eno; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129S/SvEv * FVB/N

Wwtr1^tm1.1Eno/Wwtr1^tm1.1Eno Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0 mice exhibit cardiac abnormalities and Wwtr1^tm1.1Eno/Wwtr1⁺ Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0 hearts show defects in proliferation and survival

mortality/aging

neonatal lethality, complete penetrance ( J:200670 )

• all die by P1

cardiovascular system

abnormal heart morphology ( J:200670 )

• severe cardiac defects

Genotype
MGI:5544297

cn3

• Allelic Composition: Wwtr1^tm1.1Eno/Wwtr1⁺; Yap1^tm1.1Eno/Yap1^tm1.1Eno; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129S/SvEv * FVB/N

Cardiomyopathy in Wwtr1^tm1.2Eno/Wwtr1⁺ Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0 mice

mortality/aging

postnatal lethality, complete penetrance ( J:200670 )

• die by 10 days of age

• lethality is accelerated compared to mutant mice wild type for Wwtr1

cardiovascular system

myocardium hypoplasia ( J:200670 )

• about a 60% decrease in the number of cardiomyocytes

thin myocardium ( J:200670 )

cellular

increased cardiomyocyte apoptosis ( J:200670 )

• in neonates

muscle

myocardium hypoplasia ( J:200670 )

• about a 60% decrease in the number of cardiomyocytes

thin myocardium ( J:200670 )

increased cardiomyocyte apoptosis ( J:200670 )

• in neonates

Genotype
MGI:5544296

cn4

• Allelic Composition: Wwtr1^tm1.1Eno/Wwtr1^tm1.1Eno; Yap1^tm1.1Eno/Yap1⁺; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129S/SvEv * FVB/N

Cardiomyopathy in Wwtr1^tm1.2Eno/Wwtr1^tm1.2Eno Yap1^tm1.1Eno/Yap1⁺ Tg(Myh6-cre)2182Mds/0 mice

mortality/aging

premature death ( J:200670 )

• complete lethality by 33 weeks of age from heart failure

cardiovascular system

dilated cardiomyopathy ( J:200670 )

• grossly dilated at 30 weeks of age but seen as early as 8 days of age

homeostasis/metabolism

abnormal atrial thrombosis ( J:200670 )

• at 30 weeks of age

muscle

dilated cardiomyopathy ( J:200670 )

• grossly dilated at 30 weeks of age but seen as early as 8 days of age

Genotype
MGI:5544295

cn5

• Allelic Composition: Yap1^tm1.1Eno/Yap1^tm1.1Eno; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129S/SvEv * FVB/N

Lethal cardiomyopathy in Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0 mice

mortality/aging

premature death ( J:200670 )

• die between 11 and 20 weeks of age from heart failure

cardiovascular system

thin ventricular wall ( J:200670 )

• develops by 9 weeks of age

dilated heart ventricle ( J:200670 )

• mild dilation is seen at 6 weeks of age and becomes more pronounced at 12 weeks of age

cardiac fibrosis ( J:200670 )

• develops in older mice with dilated cardiomyopathy

abnormal cardiovascular system physiology ( J:200670 )

• mild functional heart deficits by 6 weeks of age

dilated cardiomyopathy ( J:200670 )

• develops by 9 weeks of age and worsens with age

decreased cardiac muscle contractility ( J:200670 )

• mild at 6 weeks of age and becomes more pronounced at 12 weeks of age

increased myocardial infarct size ( J:200670 )

• at 26 days after permanent ligation of the left anterior descending coronary artery at P2, mice display a gross deficiency of healthy myocardial tissue throughout the LV free wall and extensive fibrotic infarct zone unlike controls that have fully regenerated by this time

behavior/neurological

lethargy ( J:200670 )

• become lethargic between 11 and 20 weeks of age

respiratory system

respiratory distress ( J:200670 )

• develops between 11 and 20 weeks of age

homeostasis/metabolism

increased myocardial infarct size ( J:200670 )

• at 26 days after permanent ligation of the left anterior descending coronary artery at P2, mice display a gross deficiency of healthy myocardial tissue throughout the LV free wall and extensive fibrotic infarct zone unlike controls that have fully regenerated by this time

abnormal atrial thrombosis ( J:200670 )

• develops in older mice with dilated cardiomyopathy

muscle

dilated cardiomyopathy ( J:200670 )

• develops by 9 weeks of age and worsens with age

decreased cardiac muscle contractility ( J:200670 )

• mild at 6 weeks of age and becomes more pronounced at 12 weeks of age