Phenotypes associated with this allele

• Allele Symbol: Gpr26^tm1Yugs
• Allele Name: targeted mutation 1, Yuguang Shi
• Allele ID: MGI:5446723
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpr26^tm1Yugs/Gpr26^tm1Yugs	involves: C57BL/6	MGI:5446724

Genotype
MGI:5446724

hm1

• Allelic Composition: Gpr26^tm1Yugs/Gpr26^tm1Yugs
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased susceptibility to diet-induced obesity ( J:189617 )

♀ • in females but not males when on a high fat diet for 12 weeks

♀ • weight is similar to controls when on a standard chow diet

adipose tissue

increased total body fat amount ( J:189617 )

♀ • in females but not males when on a high fat diet for 12 weeks

behavior/neurological

increased food intake ( J:189617 )

♀ • cumulative food intake is increased in females but not males when on a high fat diet for 12 weeks

homeostasis/metabolism

abnormal circulating hormone level ( J:189617 )

decreased circulating ghrelin level ( J:189617 )

• in males and females on a high fat diet

increased circulating insulin level ( J:189617 )

• in males and females on a high fat diet

increased circulating leptin level ( J:189617 )

♀ • in females but not males on a high fat

increased circulating cholesterol level ( J:189617 )

♀ • in females but not males on a high fat

increased circulating triglyceride level ( J:189617 )

♀ • in females but not males on a high fat

decreased energy expenditure ( J:189617 )

♀ • during the dark phase in females but not males on a high fat diet

increased susceptibility to diet-induced obesity ( J:189617 )

♀ • in females but not males when on a high fat diet for 12 weeks

♀ • weight is similar to controls when on a standard chow diet

abnormal glucose homeostasis ( J:189617 )

increased circulating glucose level ( J:189617 )

♀ • slightly higher in females on a high fat diet after an overnight fast

impaired glucose tolerance ( J:189617 )

♀ • in females but not males on a high fat diet after an overnight fast

increased physiological sensitivity to xenobiotic ( J:189617 )

♀ • females on a high fat diet are hypersensitive to the weight loss effect of a CB1 antagonist, rimonabant