Phenotypes associated with this allele

• Allele Symbol: Del(Y)2H
• Allele Name: deletion, Chr Y, 2 Harwell
• Allele ID: MGI:5446732
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Del(Y)2H/?	mixed	MGI:5446745

Genotype
MGI:5446745

ot1

• Allelic Composition: Del(Y)2H/?
• Genetic Background: mixed

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

small testis ( J:15425 )

♂ • XYY^Del(Y)2H males exhibit reduced testis size.

mortality/aging

prenatal lethality, incomplete penetrance ( J:15425 )

• XO and XY^Del(Y)2H offspring, which receive their X Chrs from the male parent, are underrepresented in litters of XY^Del(Y)2H or XXY^Del(Y)2H females by wild-type (XY) males.

reproductive system

abnormal chromosomal synapsis ( J:15425 )

• XY^Del(Y)2H females produce six classes of viable offspring: XO f, XX f, XY m, XY^Del(Y)2H f, XXY^Del(Y)2H f, XYY^Del(Y)2H m (YY^Del(Y)2H and YO would be lethal), indicating independent assortment of the sex chromosomes (likely due to failure of XY pairing during female meiosis).

arrest of male meiosis ( J:15425 )

♂ • meiotic analysis of testes of XYY^Del(Y)2H males reveals breakdown of spermatogenesis during the pachytene stage of meiosis, with near-complete absence of post-meiotic stages.

small testis ( J:15425 )

♂ • XYY^Del(Y)2H males exhibit reduced testis size.

true hermaphroditism ( J:15425 )

• ~10% of XXY^Del(Y)2H animals exhibit hemaphroditism; most of these have ambiguous external genitalia and possess ovaries plus uterus and testes with accessory male organs internally.

sex reversal ( J:15425 )

• XY^Del(Y)2H embryos develop as females.

• ~90% of XXY^Del(Y)2H embryos develop as females (and the remaining 10% as hermaphrodites).

ambiguous external genitalia ( J:15425 )

• ~10% of XXY^Del(Y)2H animals exhibit hemaphroditism; most of these have ambiguous external genitalia

abnormal fertility/fecundity ( J:15425 )

• XY^Del(Y)2H and XO female offspring from crosses of XY^Del2H females by wild-type (XY) males, which receive their X Chr from the male parent, exhibit reduced fertility.

• XXY^Del(Y)2H mice that develop as females exhibit normal fertility.

male infertility ( J:15425 )

♂ • attempts at breeding XYY^Del(Y)2H males suggest they are sterile.

cellular

abnormal chromosomal synapsis ( J:15425 )

• XY^Del(Y)2H females produce six classes of viable offspring: XO f, XX f, XY m, XY^Del(Y)2H f, XXY^Del(Y)2H f, XYY^Del(Y)2H m (YY^Del(Y)2H and YO would be lethal), indicating independent assortment of the sex chromosomes (likely due to failure of XY pairing during female meiosis).

arrest of male meiosis ( J:15425 )

♂ • meiotic analysis of testes of XYY^Del(Y)2H males reveals breakdown of spermatogenesis during the pachytene stage of meiosis, with near-complete absence of post-meiotic stages.