About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Neu3tm1Yamk
targeted mutation 1, Kazunori Yamaguchi
MGI:5446783
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Neu3tm1Yamk/Neu3tm1Yamk B6.129-Neu3tm1Yamk MGI:5446786
hm2
 		Neu3tm1Yamk/Neu3tm1Yamk involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 MGI:5446787


Genotype
MGI:5446786
hm1
Allelic
Composition		 Neu3tm1Yamk/Neu3tm1Yamk
Genetic
Background		 B6.129-Neu3tm1Yamk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neu3tm1Yamk mutation (0 available); any Neu3 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Decreased incidence of chemically induced colon tumors in Neu3tm1Yamk/Neu3tm1Yamk mice

neoplasm
neoplasm ( J:189604 )
N
• mice exhibit normal AOM- or DMH-induced aberrant crypt foci
decreased incidence of tumors by chemical induction ( J:189604 )
• mice treated with azoxymethane (AZO) and dextran sodium sulfate (DSS) exhibit reduced colon carcinogenesis

homeostasis/metabolism
decreased incidence of tumors by chemical induction ( J:189604 )
• mice treated with azoxymethane (AZO) and dextran sodium sulfate (DSS) exhibit reduced colon carcinogenesis




Genotype
MGI:5446787
hm2
Allelic
Composition		 Neu3tm1Yamk/Neu3tm1Yamk
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neu3tm1Yamk mutation (0 available); any Neu3 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:189604 )
• Background Sensitivity: mice exhibit no overt abnormalities




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory