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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Glp2rtm1.1Xfg
targeted mutation 1.1, Xinfu Guan
MGI:5446802
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Glp2rtm1.1Xfg/Glp2rtm1.1Xfg
Tg(Pomc1-cre)16Lowl/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N MGI:5446804


Genotype
MGI:5446804
cn1
Allelic
Composition
Glp2rtm1.1Xfg/Glp2rtm1.1Xfg
Tg(Pomc1-cre)16Lowl/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glp2rtm1.1Xfg mutation (0 available); any Glp2r mutation (39 available)
Tg(Pomc1-cre)16Lowl mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• accelerated gastric emptying with a dramatic shortening of half-excretion time and lag phase for a liquid meal

behavior/neurological
• increase in meal frequency but not meal size
• higher food intake during the dark cycle
• during the dark cycle

growth/size/body
• lean mass as a percent of body weight is decreased by 32 weeks of age
• late onset obesity develops after 33 weeks of age

adipose tissue

homeostasis/metabolism
• in fed mice during the dark cycle
• increase in heat production by fed mice during the dark cycle
• however, at 12 weeks of age mice fasted for 4 h show similar metabolic activity (VO2, VCO2, and heat production) to controls under inactive conditions





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory