All Phenotypes Del(Y)3H MGI Mouse

prenatal lethality, incomplete penetrance ( J:15425 )

• XO and XY^Del(Y)3H offspring, which receive their X Chrs from the male parent, are underrepresented in litters of XY^Del(Y)3H or XXY^Del(Y)3H females by wild-type (XY) males.

abnormal chromosomal synapsis ( J:15425 )

• XY^Del(Y)3H females produce six classes of viable offspring: XO f, XX f, XY m, XY^Del(Y)3H f, XXY^Del(Y)3H f, XYY^Del(Y)3H m (YY^Del(Y)3H and YO would be lethal), indicating independent assortment of the sex chromosomes (likely due to failure of XY pairing during female meiosis).

arrest of male meiosis ( J:15425 )

• meiotic analysis of testes of XYY^Del(Y)3H males reveals breakdown of spermatogenesis during the pachytene stage of meiosis, with near-complete absence of post-meiotic stages.

small testis ( J:15425 )

• XYY^Del(Y)3H males exhibit reduced testis size.

true hermaphroditism ( J:15425 )

• ~10% of XXY^Del(Y)3H animals exhibit hemaphroditism; most of these have ambiguous external genitalia and possess ovaries plus uterus and testes with accessory male organs internally.

sex reversal ( J:15425 )

• XY^Del(Y)3H embryos develop as females.

• ~90% of XXY^Del(Y)3H embryos develop as females (and the remaining 10% as hermaphrodites).

ambiguous external genitalia ( J:15425 )

• ~10% of XXY^Del(Y)3H animals exhibit hemaphroditism; most of these have ambiguous external genitalia

abnormal fertility/fecundity ( J:15425 )

• XY^Del(Y)3H and XO female offspring from crosses of XY^Del3H females by wild-type (XY) males, which receive their X Chr from the male parent, exhibit reduced fertility.

• XXY^Del(Y)3H mice that develop as females exhibit normal fertility.

male infertility ( J:15425 )

• attempts at breeding XYY^Del(Y)3H males suggest they are sterile