Phenotypes associated with this allele

• Allele Symbol: Tg(tetO-RNAi:Vegfa)#Atuf
• Allele Name: transgene insertion, Alda Tufro
• Allele ID: MGI:5446890
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(NPHS2-rtTA2*M2)1Jbk/0 Tg(tetO-RNAi:Vegfa)#Atuf/0	involves: FVB	MGI:5446897

Genotype
MGI:5446897

cx1

• Allelic Composition: Tg(NPHS2-rtTA2*M2)1Jbk/0; Tg(tetO-RNAi:Vegfa)#Atuf/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

decreased urine creatinine level ( J:189626 )

• in tamoxifen-treated mice

increased urine protein level ( J:189626 )

• in tamoxifen-treated mice

podocyte foot process effacement ( J:189626 )

• in tamoxifen-treated mice

abnormal renal glomerulus basement membrane morphology ( J:189626 )

• delamination in tamoxifen-treated mice

abnormal renal glomerulus morphology ( J:189626 )

• tamoxifen-treated mice exhibit decreased glomerular volume, mesangiolysis and glomerular microaneurisms compared with wild-type mice

abnormal glomerular filtration barrier morphology ( J:189626 )

• tamoxifen-treated mice exhibit damaged glomerular filtration barrier with swelling, vacuolization and decreased fenestration of endothelial cells; glomerular basement membrane lamination, expansion of the lamina densa, irregular thickening and interdigitations of the endothelium surface; and podocyte foot process effacement compared with wild-type mice

mesangiolysis ( J:189626 )

• in tamoxifen-treated mice

kidney failure ( J:189626 )

• in tamoxifen-treated mice

homeostasis/metabolism

increased circulating creatinine level ( J:189626 )

• in tamoxifen-treated mice

decreased urine creatinine level ( J:189626 )

• in tamoxifen-treated mice

increased urine protein level ( J:189626 )

• in tamoxifen-treated mice