Phenotypes associated with this allele

• Allele Symbol: Erbb3^{tm1.1(ERBB3)Mul}
• Allele Name: targeted mutation 1.1, William J Muller
• Allele ID: MGI:5446930
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Erbb3^tm1.1(ERBB3)Mul/Erbb3^tm1.1(ERBB3)Mul	FVB.129P2(Cg)-Erbb3^tm1.1(ERBB3)Mul	MGI:5447008
cx2	Erbb3^tm1.1(ERBB3)Mul/Erbb3^tm1.1(ERBB3)Mul Tg(MMTV-Erbb2*)NDL2-5Mul/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5447009
cx3	Erbb3^tm1.1(ERBB3)Mul/Erbb3^+ Tg(MMTV-Erbb2*)NDL2-5Mul/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5447010

Genotype
MGI:5447008

hm1

• Allelic Composition: Erbb3^{tm1.1(ERBB3)Mul}/Erbb3^{tm1.1(ERBB3)Mul}
• Genetic Background: FVB.129P2(Cg)-Erbb3^{tm1.1(ERBB3)Mul}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:189292 )

• fewer than expected mice are produced from breeding heterozygotes

integument

abnormal involution of the mammary gland ( J:189292 )

♀ • accelerated due to increased apoptosis

abnormal mammary gland growth during lactation ( J:189292 )

♀ • dams exhibit less expansion of secretory terminal alveoli (thicker epithelium with sparser and less expanded alveoli, smaller alveolar cavities and large areas of adipose tissue) that fail to fill the fat pad compared with wild-type dams

abnormal mammary gland epithelium morphology ( J:189292 )

♀ • thick in dams

abnormal mammary gland duct morphology ( J:189292 )

♀ • severe cell-autonomous mammary ductal outgrowth defect with increased apoptosis

abnormal mammary gland alveolus morphology ( J:189292 )

♀ • dams exhibit less expansion of secretory terminal alveoli (thicker epithelium with sparser and less expanded alveoli, smaller alveolar cavities and large areas of adipose tissue) that fail to fill the fat pad compared with wild-type dams

hypolactation ( J:189292 )

♀ • dams exhibit reduced milk accumulation in alveolar lumens compared with wild-type dams

increased mammary gland apoptosis ( J:189292 )

♀ • increased apoptosis in the mammary gland during involution

growth/size/body

decreased birth weight ( J:189292 )

decreased body weight ( J:189292 )

• until 6 weeks of age

postnatal growth retardation ( J:189292 )

• until 6 weeks of age

endocrine/exocrine glands

abnormal involution of the mammary gland ( J:189292 )

♀ • accelerated due to increased apoptosis

abnormal mammary gland growth during lactation ( J:189292 )

♀ • dams exhibit less expansion of secretory terminal alveoli (thicker epithelium with sparser and less expanded alveoli, smaller alveolar cavities and large areas of adipose tissue) that fail to fill the fat pad compared with wild-type dams

abnormal mammary gland epithelium morphology ( J:189292 )

♀ • thick in dams

abnormal mammary gland duct morphology ( J:189292 )

♀ • severe cell-autonomous mammary ductal outgrowth defect with increased apoptosis

abnormal mammary gland alveolus morphology ( J:189292 )

♀ • dams exhibit less expansion of secretory terminal alveoli (thicker epithelium with sparser and less expanded alveoli, smaller alveolar cavities and large areas of adipose tissue) that fail to fill the fat pad compared with wild-type dams

hypolactation ( J:189292 )

♀ • dams exhibit reduced milk accumulation in alveolar lumens compared with wild-type dams

increased mammary gland apoptosis ( J:189292 )

♀ • increased apoptosis in the mammary gland during involution

Genotype
MGI:5447009

cx2

• Allelic Composition: Erbb3^{tm1.1(ERBB3)Mul}/Erbb3^{tm1.1(ERBB3)Mul}; Tg(MMTV-Erbb2*)NDL2-5Mul/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

neoplasm

increased mammary gland tumor incidence ( J:189292 )

decreased metastatic potential ( J:189292 )

• slight reduction in lung metastasis compared to in Tg(MMTV-Erbb2*)NDL2-5Mul mice

increased tumor latency ( J:189292 )

• compared to in Tg(MMTV-Erbb2*)NDL2-5Mul mice

integument

increased mammary gland tumor incidence ( J:189292 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:189292 )

Genotype
MGI:5447010

cx3

• Allelic Composition: Erbb3^{tm1.1(ERBB3)Mul}/Erbb3⁺; Tg(MMTV-Erbb2*)NDL2-5Mul/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

neoplasm

increased mammary gland tumor incidence ( J:189292 )

increased tumor latency ( J:189292 )

• intermediate compared to in Tg(MMTV-Erbb2*)NDL2-5Mul mice

integument

increased mammary gland tumor incidence ( J:189292 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:189292 )