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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nr3c1tm1.1Jda
targeted mutation 1.1, Jonathan D Ashwell
MGI:5447468
Summary 4 genotypes


Genotype
MGI:5447539
cn1
Allelic
Composition		 Nr3c1tm1.1Jda/Nr3c1tm1.1Jda
Tg(Lck-cre)548Jxm/0
Genetic
Background		 B6.Cg-Nr3c1tm1.1Jda Tg(Lck-cre)548Jxm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1tm1.1Jda mutation (1 available); any Nr3c1 mutation (35 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte apoptosis ( J:189951 )
• double positive thymocytes are resistant to glucocorticoid-induced apoptosis compared with wild-type cells
decreased CD4-positive, alpha-beta T cell number ( J:189951 )
• modestly in the periphery
• in the thymus
decreased CD8-positive, alpha-beta T cell number ( J:189951 )
• modestly in the periphery
• in the thymus
decreased single-positive T cell number ( J:189951 )
• of mature single positive cells in the thymus
abnormal humoral immune response ( J:189951 )
• polyclonal T cells exhibit attenuated response to an antigen compared with wild-type cells

cellular
decreased thymocyte apoptosis ( J:189951 )
• double positive thymocytes are resistant to glucocorticoid-induced apoptosis compared with wild-type cells

hematopoietic system
decreased thymocyte apoptosis ( J:189951 )
• double positive thymocytes are resistant to glucocorticoid-induced apoptosis compared with wild-type cells
decreased CD4-positive, alpha-beta T cell number ( J:189951 )
• modestly in the periphery
• in the thymus
decreased CD8-positive, alpha-beta T cell number ( J:189951 )
• modestly in the periphery
• in the thymus
decreased single-positive T cell number ( J:189951 )
• of mature single positive cells in the thymus

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:189951 )
• double positive thymocytes are resistant to glucocorticoid-induced apoptosis compared with wild-type cells




Genotype
MGI:5447540
cn2
Allelic
Composition		 Nr3c1tm1.1Jda/Nr3c1+
Tg(Lck-cre)548Jxm/0
Genetic
Background		 B6.Cg-Nr3c1tm1.1Jda Tg(Lck-cre)548Jxm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1tm1.1Jda mutation (1 available); any Nr3c1 mutation (35 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte apoptosis ( J:189951 )
• thymocytes are less sensitive to dexamethasone-induced apoptosis compared with wild-type cells

cellular
decreased thymocyte apoptosis ( J:189951 )
• thymocytes are less sensitive to dexamethasone-induced apoptosis compared with wild-type cells

hematopoietic system
decreased thymocyte apoptosis ( J:189951 )
• thymocytes are less sensitive to dexamethasone-induced apoptosis compared with wild-type cells

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:189951 )
• thymocytes are less sensitive to dexamethasone-induced apoptosis compared with wild-type cells




Genotype
MGI:5447537
cn3
Allelic
Composition		 Nr3c1tm1.1Jda/Nr3c1tm1.1Jda
Rag2tm1.1Cgn/Rag2tm1.1Cgn
Tg(Lck-cre)548Jxm/0
Tg(TcrAND)53Hed/0
Genetic
Background		 B6.Cg-Rag2tm1.1Cgn Nr3c1tm1.1Jda Tg(Lck-cre)548Jxm Tg(TcrAND)53Hed
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1tm1.1Jda mutation (1 available); any Nr3c1 mutation (35 available)
Rag2tm1.1Cgn mutation (4 available); any Rag2 mutation (119 available)
Tg(Lck-cre)548Jxm mutation (2 available)
Tg(TcrAND)53Hed mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system

hematopoietic system




Genotype
MGI:5447538
cn4
Allelic
Composition		 Nr3c1tm1.1Jda/Nr3c1tm1.1Jda
Tcratm1Mom/Tcratm1Mom
Tg(Lck-cre)548Jxm/0
Genetic
Background		 B6.Cg-Tcratm1Mom Nr3c1tm1.1Jda Tg(Lck-cre)548Jxm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1tm1.1Jda mutation (1 available); any Nr3c1 mutation (35 available)
Tcratm1Mom mutation (6 available); any Tcra mutation (101 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system

hematopoietic system




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory