About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(Pyy)Paba
targeted mutation 1, Paul A Baldock
MGI:5447471
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(Pyy)Paba involves: 129S4/SvJae MGI:5447473


Genotype
MGI:5447473
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(Pyy)Paba
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Tyj mutation (3 available); any Gt(ROSA)26Sor mutation (993 available)
Gt(ROSA)26Sortm1(Pyy)Paba mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Lower bone mass and reduced bone size in Gt(ROSA)26Sortm1(Pyy)Paba/Gt(ROSA)26Sortm1(cre/ERT2)Tyj females

growth/size/body
decreased lean body mass ( J:189512 )
• in females prior to tamoxifen treatment

skeleton
short femur ( J:189512 )
• in females after tamoxifen treatment
small vertebrae ( J:189512 )
• decrease in vertebral height in females after tamoxifen treatment
abnormal osteoclast morphology ( J:189512 )
• increase in osteoclast surface in the femoral metaphysis in tamoxifen treated males and females
increased osteoclast cell number ( J:189512 )
• in tamoxifen treated females
decreased bone mineral density of femur ( J:189512 )
• decreased bone mineral density in the femur of females after tamoxifen treatment
decreased trabecular bone volume ( J:189512 )
• in the distal femora and lumbar vertebrae in tamoxifen treated females
decreased compact bone area ( J:189512 )
• in tamoxifen treated females
abnormal bone mineralization ( J:189512 )
• decrease in the mineral apposition rate in the distal femoral metaphysis of tamoxifen treated males and females
• cancellous bone formation rate and mid-femoral endocortical MAR are decreased in tamoxifen treated females
decreased bone strength ( J:189512 )
• reduced mean polar moment of inertia in tamoxifen treated females

hematopoietic system
abnormal osteoclast morphology ( J:189512 )
• increase in osteoclast surface in the femoral metaphysis in tamoxifen treated males and females
increased osteoclast cell number ( J:189512 )
• in tamoxifen treated females

immune system
abnormal osteoclast morphology ( J:189512 )
• increase in osteoclast surface in the femoral metaphysis in tamoxifen treated males and females
increased osteoclast cell number ( J:189512 )
• in tamoxifen treated females

limbs/digits/tail
short femur ( J:189512 )
• in females after tamoxifen treatment




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory