Phenotypes associated with this allele

• Allele Symbol: Cd5^tm1.1Chra
• Allele Name: targeted mutation 1.1, Chander Raman
• Allele ID: MGI:5447646
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd5^tm1.1Chra/Cd5^tm1.1Chra	involves: C57BL/6 * FVB/N	MGI:5447725
cx2	Cd5^tm1.1Chra/Cd5^tm1.1Chra Tg(Tcra2D2,Tcrb2D2)1Kuch/0	involves: C57BL/6 * FVB/N	MGI:5447726

Genotype
MGI:5447725

hm1

• Allelic Composition: Cd5^tm1.1Chra/Cd5^tm1.1Chra
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased double-negative T cell number ( J:189919 )

decreased double-positive T cell number ( J:189919 )

decreased B cell number ( J:189919 )

• in the spleen

decreased follicular B cell number ( J:189919 )

decreased CD4-positive, alpha-beta T cell number ( J:189919 )

• in the lymph node

decreased T-helper 17 cell number ( J:189919 )

• in MOG35-55-treated mice

abnormal T cell physiology ( J:189919 )

• following TCR stimulation, T cells exhibit lower threshold for calcium flux compared with wild-type cells

decreased T cell proliferation ( J:189919 )

• in response to antigen receptor activation

increased T cell proliferation ( J:189919 )

• in CD4+ T cells stimulated with anti-CD3 or cognate peptide, rested then restimulated with anti-CD3 or MOG35-55

• in CD8+ T cells when restimulated

abnormal T cell anergy ( J:189919 )

• T cells treated with anti-CD3 or MOG35-55 are resistant to development of anergy

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:189919 )

• delayed onset and reduced severity of MOG35-55-induced experimental autoimmune encephalomyelitis with fewer Th17 cells in the spinal cord

hematopoietic system

increased double-negative T cell number ( J:189919 )

decreased double-positive T cell number ( J:189919 )

decreased B cell number ( J:189919 )

• in the spleen

decreased follicular B cell number ( J:189919 )

decreased CD4-positive, alpha-beta T cell number ( J:189919 )

• in the lymph node

decreased T-helper 17 cell number ( J:189919 )

• in MOG35-55-treated mice

abnormal T cell physiology ( J:189919 )

• following TCR stimulation, T cells exhibit lower threshold for calcium flux compared with wild-type cells

decreased T cell proliferation ( J:189919 )

• in response to antigen receptor activation

increased T cell proliferation ( J:189919 )

• in CD4+ T cells stimulated with anti-CD3 or cognate peptide, rested then restimulated with anti-CD3 or MOG35-55

• in CD8+ T cells when restimulated

cellular

decreased T cell proliferation ( J:189919 )

• in response to antigen receptor activation

increased T cell proliferation ( J:189919 )

• in CD4+ T cells stimulated with anti-CD3 or cognate peptide, rested then restimulated with anti-CD3 or MOG35-55

• in CD8+ T cells when restimulated

Genotype
MGI:5447726

cx2

• Allelic Composition: Cd5^tm1.1Chra/Cd5^tm1.1Chra; Tg(Tcra2D2,Tcrb2D2)1Kuch/0
• Genetic Background: involves: C57BL/6 * FVB/N

immune system

decreased T cell proliferation ( J:189919 )

• in CD4+ T cells stimulated with anti-CD3

decreased T helper 1 cell number ( J:189919 )

• under nonpolarizing conditions

decreased interferon-gamma secretion ( J:189919 )

• in CD4+ T cells under nonpolarizing conditions

increased interferon-gamma secretion ( J:189919 )

• in CD4+ T cells stimulated with MOG35-55 compared with cells from wild-type control but not as much as in cells from Cd5^tm1Cgn/Cd5^tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice

increased interleukin-17 secretion ( J:189919 )

• in CD4+ T cells stimulated with MOG35-55 compared with cells from wild-type control but not as much as in cells from Cd5^tm1Cgn/Cd5^tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice

decreased interleukin-2 secretion ( J:189919 )

• IL2 levels from CD4+ T cells stimulated with MOG35-55 do not persist as long as in cells from wild-type mice

increased interleukin-6 secretion ( J:189919 )

• in CD4+ T cells stimulated with MOG35-55 compared with cells from wild-type control but not as much as in cells from Cd5^tm1Cgn/Cd5^tm1Cgn Tg(Tcra2D2,Tcrb2D2)1Kuch mice

hematopoietic system

decreased T cell proliferation ( J:189919 )

• in CD4+ T cells stimulated with anti-CD3

decreased T helper 1 cell number ( J:189919 )

• under nonpolarizing conditions

cellular

decreased T cell proliferation ( J:189919 )

• in CD4+ T cells stimulated with anti-CD3