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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Serpinb3atm1Gsil
targeted mutation 1, Gary A Silverman
MGI:5447741
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Serpinb3atm1Gsil/Serpinb3atm1Gsil C.129-Serpinb3atm1Gsil MGI:5447744


Genotype
MGI:5447744
hm1
Allelic
Composition		 Serpinb3atm1Gsil/Serpinb3atm1Gsil
Genetic
Background		 C.129-Serpinb3atm1Gsil
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpinb3atm1Gsil mutation (1 available); any Serpinb3a mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
decreased respiratory mucosa goblet cell number ( J:189949 )
• following house dust-mite challenge
decreased airway responsiveness ( J:189949 )
• house dust mite- or IL13-induced airway hyperresponsiveness is attenuated
• however, house dust mite-induced allergen sensitization and inflammation are normal

immune system
decreased susceptibility to type I hypersensitivity reaction ( J:189949 )
• mice exposed to house dust mite exhibit attenuated airway hyperresponsiveness and reduced mucus-producing goblet cell hyperplasia compared with wild-type mice
• IL13-treated mice exhibit attenuated airway hyperresponsiveness, reduced inflammatory cells in the bronchoalveolar lavage fluid and reduced mucin production compared with wild-type mice
• however, house dust mite-induced allergen sensitization and inflammation are normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory