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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Siglec1tm2.1Croc
targeted mutation 2.1, Paul R Crocker
MGI:5447769
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Siglec1tm2.1Croc/Siglec1tm2.1Croc B6.129P2(C)-Siglec1tm2.1Croc MGI:5447804


Genotype
MGI:5447804
hm1
Allelic
Composition		 Siglec1tm2.1Croc/Siglec1tm2.1Croc
Genetic
Background		 B6.129P2(C)-Siglec1tm2.1Croc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Siglec1tm2.1Croc mutation (0 available); any Siglec1 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired macrophage phagocytosis ( J:189854 )
• bone marrow-derived macrophage exhibit reduced uptake of sialylated C. jejuni compared with wild-type cells
• however, phagocytosis of IgG-opsonized E. coli is normal
decreased circulating interleukin-6 level ( J:189854 )
• in mice exposed to C. jejuni
decreased circulating tumor necrosis factor level ( J:189854 )
• in mice exposed to C. jejuni
decreased susceptibility to bacterial infection ( J:189854 )
• bone marrow-derived macrophage exhibit reduced uptake of sialylated C. jejuni compared with wild-type cells
• mice exposed to C. jejuni exhibit reduced serum levels of TNF and IL6 and reduced burden in the spleen and liver (at 5 but not 20 minutes after inspection) compared with wild-type mice
• however, phagocytosis of IgG-opsonized E. coli is normal

homeostasis/metabolism
decreased circulating interleukin-6 level ( J:189854 )
• in mice exposed to C. jejuni
decreased circulating tumor necrosis factor level ( J:189854 )
• in mice exposed to C. jejuni

hematopoietic system
impaired macrophage phagocytosis ( J:189854 )
• bone marrow-derived macrophage exhibit reduced uptake of sialylated C. jejuni compared with wild-type cells
• however, phagocytosis of IgG-opsonized E. coli is normal

cellular
impaired macrophage phagocytosis ( J:189854 )
• bone marrow-derived macrophage exhibit reduced uptake of sialylated C. jejuni compared with wild-type cells
• however, phagocytosis of IgG-opsonized E. coli is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory