Phenotypes associated with this allele

• Allele Symbol: Havcr2^tm1Bmed
• Allele Name: targeted mutation 1, Benjamin D Medoff
• Allele ID: MGI:5447924
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Havcr2^tm1Bmed/Havcr2^tm1Bmed	B6.Cg-Havcr2^tm1Bmed	MGI:5447947

Genotype
MGI:5447947

hm1

• Allelic Composition: Havcr2^tm1Bmed/Havcr2^tm1Bmed
• Genetic Background: B6.Cg-Havcr2^tm1Bmed

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:189839 )

• in mice exposed to influenza infection

immune system

decreased activation-induced cell death of T cells ( J:189839 )

• galectin-9-mediated apoptosis of CD8+ T cells

decreased T cell proliferation ( J:189839 )

• of CD8+ T cells from the lungs of mice infected with influenza

abnormal CD8-positive, alpha-beta T cell physiology ( J:189839 )

• in adoptive transfer experiments, CD8+ T cells exhibit decreased effector function compared with wild-type cells

• however, functional heterotypic immunity is intact

decreased interferon-gamma secretion ( J:189839 )

• in CD8+ T cells from the lungs of mice infected with WSN-ovalbumin

• in PMA and ionomycin stimulation of CD8+ T cells

decreased susceptibility to Orthomyxoviridae infection ( J:189839 )

• mice exposed to influenza infection exhibit reduced morbidity and mortality compared with wild-type mice

• mice infected with a non-lethal dose of x31 virus (an H3N2 subtype) then challenged with a lethal dose of PR8 (an H1N1 subtype) exhibit reduced weight loss during acute PR8 infection and no weight loss during secondary infection compared with wild-type mice

• however, mice exhibit normal viral clearance

decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:189839 )

• in mice exposed to influenza infection

growth/size/body

decreased susceptibility to weight loss ( J:189839 )

• mice infected with a non-lethal dose of x31 virus (an H3N2 subtype) then challenged with a lethal dose of PR8 (an H1N1 subtype) exhibit reduced weight loss during acute PR8 infection and no weight loss during secondary infection compared with wild-type mice

cellular

decreased activation-induced cell death of T cells ( J:189839 )

• galectin-9-mediated apoptosis of CD8+ T cells

decreased T cell proliferation ( J:189839 )

• of CD8+ T cells from the lungs of mice infected with influenza

hematopoietic system

decreased activation-induced cell death of T cells ( J:189839 )

• galectin-9-mediated apoptosis of CD8+ T cells

decreased T cell proliferation ( J:189839 )

• of CD8+ T cells from the lungs of mice infected with influenza

abnormal CD8-positive, alpha-beta T cell physiology ( J:189839 )

• in adoptive transfer experiments, CD8+ T cells exhibit decreased effector function compared with wild-type cells

• however, functional heterotypic immunity is intact