Phenotypes associated with this allele

• Allele Symbol: Vav1^tm4Tyb
• Allele Name: targeted mutation 4, Victor Tybulewicz
• Allele ID: MGI:5447927
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vav1^tm4Tyb/Vav1^tm4Tyb	either: 129S8.129S4-Vav1^tm4Tyb or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)	MGI:5448158

Genotype
MGI:5448158

hm1

• Allelic Composition: Vav1^tm4Tyb/Vav1^tm4Tyb
• Genetic Background: either: 129S8.129S4-Vav1^tm4Tyb or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal lymphocyte cell number ( J:190087 )

abnormal T cell number ( J:190087 )

• large decrease of single "+" cells in thymus, spleen, and lymph nodes

increased DN2 thymocyte number ( J:190087 )

• modest increase

increased DN3 thymocyte number ( J:190087 )

• modest increase

abnormal immune system physiology ( J:190087 )

abnormal T cell physiology ( J:190087 )

abnormal CD4-positive, alpha-beta T cell physiology ( J:190087 )

• TCR induced proliferation of CD4+ cells is reduced

abnormal CD8-positive, alpha-beta T cell physiology ( J:190087 )

• reduced ability of CD8+ cells to form conjugates with antigen presenting cells

abnormal immune serum protein physiology ( J:190087 )

increased circulating interferon-gamma level ( J:190087 )

• relative to controls and Vav1^tm1Tyb homozygotes

abnormal interleukin-2 secretion ( J:190087 )

• modestly reduced

hematopoietic system

abnormal lymphocyte cell number ( J:190087 )

abnormal T cell number ( J:190087 )

• large decrease of single "+" cells in thymus, spleen, and lymph nodes

increased DN2 thymocyte number ( J:190087 )

• modest increase

increased DN3 thymocyte number ( J:190087 )

• modest increase

abnormal T cell physiology ( J:190087 )

abnormal CD4-positive, alpha-beta T cell physiology ( J:190087 )

• TCR induced proliferation of CD4+ cells is reduced

abnormal CD8-positive, alpha-beta T cell physiology ( J:190087 )

• reduced ability of CD8+ cells to form conjugates with antigen presenting cells

homeostasis/metabolism

increased circulating interferon-gamma level ( J:190087 )

• relative to controls and Vav1^tm1Tyb homozygotes

endocrine/exocrine glands

increased DN2 thymocyte number ( J:190087 )

• modest increase

increased DN3 thymocyte number ( J:190087 )

• modest increase