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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chit1tm1Eli
targeted mutation 1, Jack A Elias
MGI:5447948
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Chit1tm1Eli/Chit1tm1Eli involves: C57BL/6 MGI:5447951
cx2
 		Chit1tm1Eli/Chit1tm1Eli
Tg(Scgb1a1-rtTA,tetO-CHIT1)#Eli/0 		involves: C57BL/6 MGI:5447952
cx3
 		Chit1tm1Eli/Chit1tm1Eli
Tg(Scgb1a1-Il13)2Eli/0 		involves: C57BL/6 * CBA MGI:5447953


Genotype
MGI:5447951
hm1
Allelic
Composition		 Chit1tm1Eli/Chit1tm1Eli
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chit1tm1Eli mutation (0 available); any Chit1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to bacterial infection ( J:189872 )
• bleomycin-treated mice exhibit reduced pulmonary fibrosis compared with control mice
• however, bleomycin-induced inflammation is normal




Genotype
MGI:5447952
cx2
Allelic
Composition		 Chit1tm1Eli/Chit1tm1Eli
Tg(Scgb1a1-rtTA,tetO-CHIT1)#Eli/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chit1tm1Eli mutation (0 available); any Chit1 mutation (32 available)
Tg(Scgb1a1-rtTA,tetO-CHIT1)#Eli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to bacterial infection ( J:189872 )
• doxycycline-treated mice exhibit exacerbated bleomycin-induced pulmonary fibrosis compared with Tg(Scgb1a1-rtTA,tetO-CHIT1)#Eli mice
• however, bleomycin-induced inflammation is normal




Genotype
MGI:5447953
cx3
Allelic
Composition		 Chit1tm1Eli/Chit1tm1Eli
Tg(Scgb1a1-Il13)2Eli/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chit1tm1Eli mutation (0 available); any Chit1 mutation (32 available)
Tg(Scgb1a1-Il13)2Eli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to bacterial infection ( J:189872 )
• bleomycin-treated mice exhibit reduced pulmonary fibrosis and inflammation compared with control mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory