Phenotypes associated with this allele

• Allele Symbol: Dppa3^tm1(rtTA)Nkn
• Allele Name: targeted mutation 1, Toru Nakano
• Allele ID: MGI:5448272
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dppa3^tm1(rtTA)Nkn/Dppa3^tm1(rtTA)Nkn	involves: 129S2/SvPas * C57BL/6	MGI:5448273

Genotype
MGI:5448273

hm1

• Allelic Composition: Dppa3^tm1(rtTA)Nkn/Dppa3^tm1(rtTA)Nkn
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

failure of zygotic cell division ( J:189990 )

• only 3% of E0.5 embryos cultured for 4 days reach the blastocyst stage

• most embryos fragment or show abnormal cleavage at the 2-4 cell stage

cellular

abnormal DNA methylation ( J:189990 )

• methylation status of the maternal and paternal genomes of null zygotes is reduced compared to control zygotes

• however, methylation of oocytes before fertilization is similar to controls