About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dppa3tm1(rtTA)Nkn
targeted mutation 1, Toru Nakano
MGI:5448272
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dppa3tm1(rtTA)Nkn/Dppa3tm1(rtTA)Nkn involves: 129S2/SvPas * C57BL/6 MGI:5448273


Genotype
MGI:5448273
hm1
Allelic
Composition
Dppa3tm1(rtTA)Nkn/Dppa3tm1(rtTA)Nkn
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dppa3tm1(rtTA)Nkn mutation (1 available); any Dppa3 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• only 3% of E0.5 embryos cultured for 4 days reach the blastocyst stage
• most embryos fragment or show abnormal cleavage at the 2-4 cell stage

cellular
• methylation status of the maternal and paternal genomes of null zygotes is reduced compared to control zygotes
• however, methylation of oocytes before fertilization is similar to controls





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory