Phenotypes associated with this allele

• Allele Symbol: Tg(Col11a2-Npr2*)28Keoz
• Allele Name: transgene insertion 28, Keiichi Ozono
• Allele ID: MGI:5448404
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Col11a2-Npr2*)28Keoz/0	involves: C57BL/6	MGI:5448405

Genotype
MGI:5448405

tg1

• Allelic Composition: Tg(Col11a2-Npr2*)28Keoz/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Skeletal abnormalities in Tg(Col11a2-Npr2*)28Keoz/0 mice

growth/size/body

increased body length ( J:189658 )

• from 8 to 18 weeks of age

skeleton

abnormal neurocranium morphology ( J:189658 )

• naso-occipital length of the calvarium is increased

abnormal long bone morphology ( J:189658 )

abnormal phalanx morphology ( J:189658 )

• long phalanges from 8 to 18 weeks of age

long femur ( J:189658 )

• at 18 weeks of age

long tibia ( J:189658 )

• at 18 weeks of age

abnormal long bone hypertrophic chondrocyte zone ( J:189658 )

• disorganized arrangement of chondrocytes with increased number of hypertrophic chondrocytes

disorganized long bone epiphyseal plate ( J:189658 )

increased long bone epiphyseal plate size ( J:189658 )

• wider in the femur and tibia at 8 weeks of age

kyphosis ( J:189658 )

• severe in adults

abnormal vertebrae morphology ( J:189658 )

• spinal and tail vertebrae are longer compared to wild-type from 8 to 18 weeks of age

limbs/digits/tail

abnormal phalanx morphology ( J:189658 )

• long phalanges from 8 to 18 weeks of age

long femur ( J:189658 )

• at 18 weeks of age

long tibia ( J:189658 )

• at 18 weeks of age

long tail ( J:189658 )

• from 8 to 18 weeks of age

behavior/neurological

abnormal locomotor behavior ( J:189658 )

• severe claudication (limping) in the legs in adults

craniofacial

abnormal neurocranium morphology ( J:189658 )

• naso-occipital length of the calvarium is increased

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
bone development disease		DOID:0080006		J:189658