Phenotypes associated with this allele

• Allele Symbol: Tg(ACTA2-rtTA)#Des
• Allele Name: transgene insertion, Dean Sheppard
• Allele ID: MGI:5448425
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Itga9^tm2Des/Itga9^tm2Des Tg(ACTA2-rtTA)#Des/0 Tg(tetO-cre)1Jaw/0	involves: 129 * 129S4/SvJae * C57BL/6	MGI:5448443

Genotype
MGI:5448443

cn1

• Allelic Composition: Itga9^tm2Des/Itga9^tm2Des; Tg(ACTA2-rtTA)#Des/0; Tg(tetO-cre)1Jaw/0
• Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

respiratory system phenotype ( J:190074 )

N • mice exhibit normal airway epithelium morphology and no evidence of inflammation

abnormal respiratory system morphology ( J:190074 )

• methacholine-treated mice exhibit increased narrowing in airways compared with control mice

• lung slices treated with methacholine in vitro exhibit increased narrowing compared with control slices

• spermine has no increase in contraction unlike in control samples

• however, putrescine has no effect on airway contraction

abnormal respiratory system physiology ( J:190074 )

• excised tracheal rings (with or without epithelium) treated with methacholine exhibit increased in vitro force generation compared with control rings

• lung slices and tracheal rings exhibit increased contractile response to 5-HT compared with control samples

increased airway responsiveness ( J:190074 )

• in response to acetylcholine