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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mir122tm1.1Kgh
targeted mutation 1.1, Kalpana Ghoshal
MGI:5448467
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mir122tm1.1Kgh/Mir122tm1.1Kgh involves: 129S1/Sv * 129X1/SvJ MGI:5448538
ht2
Mir122tm1.1Kgh/Mir122+ involves: 129S1/Sv * 129X1/SvJ MGI:5448539


Genotype
MGI:5448538
hm1
Allelic
Composition
Mir122tm1.1Kgh/Mir122tm1.1Kgh
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir122tm1.1Kgh mutation (0 available); any Mir122 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Mir122tm1.1Kgh/Mir122tm1.1Kgh mice develop hepatitis and fibrosis with age

homeostasis/metabolism
• as early as 5 weeks of age
• as early as 5 weeks of age
• in tumor-bearing male mice
• increase in serum gamma-glutamyl transpeptidase
• at 5 weeks
• at 6 months
• in tumor-bearing mice
• in tumor-bearing mice

liver/biliary system
• steatohepatitis with fibrosis
• 10 of 20 male mice at 11 to 15 months
• 9 of 19 female mice at 11 to 15 months
• tumor weight and grade is higher in male mice compared with female mice

neoplasm
• 10 of 20 male mice at 11 to 15 months
• 9 of 19 female mice at 11 to 15 months
• tumor weight and grade is higher in male mice compared with female mice
• tumor weight and grade is higher in male mice compared with female mice

immune system
• in tumor-bearing male mice
• steatohepatitis with fibrosis




Genotype
MGI:5448539
ht2
Allelic
Composition
Mir122tm1.1Kgh/Mir122+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir122tm1.1Kgh mutation (0 available); any Mir122 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• in 1 of 20 mice at 5 months

liver/biliary system
• in 1 of 20 mice at 5 months





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory