Phenotypes associated with this allele

• Allele Symbol: Rad21l^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5448653
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rad21l^tm1b(KOMP)Wtsi/Rad21l^tm1b(KOMP)Wtsi	B6N(Cg)-Rad21l^tm1b(KOMP)Wtsi	MGI:6506388
hm2	Rad21l^tm1b(KOMP)Wtsi/Rad21l^tm1b(KOMP)Wtsi	C57BL/6N-Rad21l^tm1b(KOMP)Wtsi/J	MGI:5631467
cx3	Prdm9^tm1Ymat/Prdm9^tm1Ymat Rad21l^tm1b(KOMP)Wtsi/Rad21l^tm1b(KOMP)Wtsi	B6.Cg-Prdm9^tm1Ymat Rad21l^tm1b(KOMP)Wtsi	MGI:6506404
cx4	Rad21l^tm1b(KOMP)Wtsi/Rad21l^tm1b(KOMP)Wtsi Rec8^tm1b(KOMP)Wtsi/Rec8^tm1b(KOMP)Wtsi	B6N(Cg)-Rad21l^tm1b(KOMP)Wtsi Rec8^tm1b(KOMP)Wtsi	MGI:6506394
cx5	Rad21l^tm1b(KOMP)Wtsi/Rad21l^tm1b(KOMP)Wtsi Stag3^tm1e.1(KOMP)Wtsi/Stag3^tm1e.1(KOMP)Wtsi	B6N(Cg)-Rad21l^tm1b(KOMP)Wtsi Stag3^tm1e.1(KOMP)Wtsi	MGI:6506392

Genotype
MGI:6506388

hm1

• Allelic Composition: Rad21l^{tm1b(KOMP)Wtsi}/Rad21l^{tm1b(KOMP)Wtsi}
• Genetic Background: B6N(Cg)-Rad21l^{tm1b(KOMP)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:280261 )

♂N • normal number of double-strand DNA breaks in spermatocytes

Genotype
MGI:5631467

hm2

• Allelic Composition: Rad21l^{tm1b(KOMP)Wtsi}/Rad21l^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Rad21l^{tm1b(KOMP)Wtsi}/J
• Cell Lines: EPD0399_1_C12

Data Sources

IMPC Data for Rad21l

homeostasis/metabolism

decreased circulating glucose level ( J:211773 )

♂

IMPC - JAX

decreased circulating chloride level ( J:211773 )

IMPC - JAX

reproductive system

male infertility ( J:211773 )

♂

IMPC - JAX

Genotype
MGI:6506404

cx3

• Allelic Composition: Prdm9^tm1Ymat/Prdm9^tm1Ymat; Rad21l^{tm1b(KOMP)Wtsi}/Rad21l^{tm1b(KOMP)Wtsi}
• Genetic Background: B6.Cg-Prdm9^tm1Ymat Rad21l^{tm1b(KOMP)Wtsi}

cellular

cellular phenotype ( J:280261 )

♂N • normal number of double-strand DNA breaks in spermatocytes

Genotype
MGI:6506394

cx4

• Allelic Composition: Rad21l^{tm1b(KOMP)Wtsi}/Rad21l^{tm1b(KOMP)Wtsi}; Rec8^{tm1b(KOMP)Wtsi}/Rec8^{tm1b(KOMP)Wtsi}
• Genetic Background: B6N(Cg)-Rad21l^{tm1b(KOMP)Wtsi} Rec8^{tm1b(KOMP)Wtsi}

cellular

abnormal double-strand DNA break repair ( J:280261 )

♂ • reduced number of double-strand DNA breaks (20-30% of WT or single KO) in spermatocytes

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:280261 )

♂ • reduced number of double-strand DNA breaks (20-30% of WT or single KO) in spermatocytes

Genotype
MGI:6506392

cx5

• Allelic Composition: Rad21l^{tm1b(KOMP)Wtsi}/Rad21l^{tm1b(KOMP)Wtsi}; Stag3^{tm1e.1(KOMP)Wtsi}/Stag3^{tm1e.1(KOMP)Wtsi}
• Genetic Background: B6N(Cg)-Rad21l^{tm1b(KOMP)Wtsi} Stag3^{tm1e.1(KOMP)Wtsi}

reproductive system

abnormal synaptonemal complex ( J:280261 )

♂ • absence of linear SC, forming instead a more punctuate SC around centromeres in spermatocytes

cellular

abnormal synaptonemal complex ( J:280261 )

♂ • absence of linear SC, forming instead a more punctuate SC around centromeres in spermatocytes

abnormal double-strand DNA break repair ( J:280261 )

♂ • reduced number of double-strand DNA breaks (77% of WT) in spermatocytes

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:280261 )

♂ • reduced number of double-strand DNA breaks (77% of WT) in spermatocytes