Phenotypes associated with this allele

• Allele Symbol: Akap5^tm1Mdaq
• Allele Name: targeted mutation 1, Mark Dell'Acqua
• Allele ID: MGI:5448682
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Akap5^tm1Mdaq/Akap5^tm1Mdaq	involves: 129 * C57BL/6	MGI:5702308
hm2	Akap5^tm1Mdaq/Akap5^tm1Mdaq	involves: 129 * C57BL/6 * C57BL/6J	MGI:5448696

Genotype
MGI:5702308

hm1

• Allelic Composition: Akap5^tm1Mdaq/Akap5^tm1Mdaq
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:191219 )

N • mice exhibit no gross abnormalities in brain structure and anatomy, neuronal organization and basal synaptic transmission

abnormal synaptic plasticity ( J:191219 )

abnormal excitatory postsynaptic potential ( J:191219 )

• following 10 Hz or 1 Hz low-frequency stimulation, sections fail to exhibit an initial decrease in field excitatory postsynaptic potential (sEPSP) slope compared with sections from wild-type mice

• following 1 Hz paired pulse low-frequency stimulation, slices exhibit less of a decrease in sEPSP slope compared with slices from wild-type mice

• fEPSPs fail to return to pre-long term potentiation baseline after low frequency stimulation as in slices from wild-type mice

abnormal AMPA-mediated synaptic currents ( J:191219 )

• basal synaptic activity of Gria2-lacking AMPA receptors is increased compared to in wild-type mice

enhanced long-term potentiation ( J:191219 )

• following 1 x 100 Hz, 1 s high frequency stimulation NMDAR-dependent long term potentiation is enhanced compared to in slices from wild-type mice

• however, no difference is observed with 50 Hz, 2 s stimulation

absent long-term depression ( J:191219 )

• following 1 Hz low-frequency stimulation

• however, there is no significant LTP or LTD relative to baseline following 10 Hz stimulation

reduced long-term depression ( J:191219 )

• following 1 Hz paired pulse with a 50 ms interpulse interval

Genotype
MGI:5448696

hm2

• Allelic Composition: Akap5^tm1Mdaq/Akap5^tm1Mdaq
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

homeostasis/metabolism

decreased insulin secretion ( J:190017 )

♂ • from glucose stimulated islets

decreased circulating insulin level ( J:190017 )

♂ • following glucose challenge

improved glucose tolerance ( J:190017 )

♂

increased insulin sensitivity ( J:190017 )

♂

endocrine/exocrine glands

decreased insulin secretion ( J:190017 )

♂ • from glucose stimulated islets