About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kdm6atm1.1Kaig
targeted mutation 1.1, Kai Ge
MGI:5448754
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kdm6atm1.1Kaig/Kdm6atm1.1Kaig involves: 129S4/SvJaeSor MGI:5448829
cn2
 		Kdm6atm1.1Kaig/Kdm6atm1.1Kaig
Pax7tm2.1(cre/ERT2)Fan/Pax7+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5779968
cn3
 		Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
Kdm6atm1.1Kaig/Y
Pax7tm2.1(cre/ERT2)Fan/Pax7+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5779969
cn4
 		Kdm6atm1.1Kaig/Y
Pax7tm2.1(cre/ERT2)Fan/Pax7+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5779970
ot5
 		Kdm6atm1.1Kaig/Y involves: 129S4/SvJaeSor MGI:5488641


Genotype
MGI:5448829
hm1
Allelic
Composition		 Kdm6atm1.1Kaig/Kdm6atm1.1Kaig
Genetic
Background		 involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6atm1.1Kaig mutation (1 available); any Kdm6a mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:190157 )
• mice are indistinguishable from wild-type mice




Genotype
MGI:5779968
cn2
Allelic
Composition		 Kdm6atm1.1Kaig/Kdm6atm1.1Kaig
Pax7tm2.1(cre/ERT2)Fan/Pax7+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6atm1.1Kaig mutation (1 available); any Kdm6a mutation (40 available)
Pax7tm2.1(cre/ERT2)Fan mutation (1 available); any Pax7 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal muscle precursor cell morphology ( J:232700 )
• muscle progenitor cells fail to differentiate ex vitro
impaired skeletal muscle regeneration ( J:232700 )
• following CTX-induced muscle injury, tamoxifen-treated mice exhibit decreased myofiber density with increased necrotic tissues and inflammatory cell infiltration compared with control mice
• however, mice exhibit regeneration of smaller caliber myofibers




Genotype
MGI:5779969
cn3
Allelic
Composition		 Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
Kdm6atm1.1Kaig/Y
Pax7tm2.1(cre/ERT2)Fan/Pax7+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo mutation (10 available); any Gt(ROSA)26Sor mutation (993 available)
Kdm6atm1.1Kaig mutation (1 available); any Kdm6a mutation (40 available)
Pax7tm2.1(cre/ERT2)Fan mutation (1 available); any Pax7 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
impaired skeletal muscle regeneration ( J:232700 )
• in tamoxifen-treated mice following CTX-induced muscle injury




Genotype
MGI:5779970
cn4
Allelic
Composition		 Kdm6atm1.1Kaig/Y
Pax7tm2.1(cre/ERT2)Fan/Pax7+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6atm1.1Kaig mutation (1 available); any Kdm6a mutation (40 available)
Pax7tm2.1(cre/ERT2)Fan mutation (1 available); any Pax7 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal muscle precursor cell morphology ( J:232700 )
• muscle progenitor cells fail to differentiate ex vitro
impaired skeletal muscle regeneration ( J:232700 )
• following CTX-induced muscle injury, tamoxifen-treated mice exhibit decreased myofiber density with increased necrotic tissues and inflammatory cell infiltration compared with control mice
• however, mice exhibit regeneration of smaller caliber myofibers




Genotype
MGI:5488641
ot5
Allelic
Composition		 Kdm6atm1.1Kaig/Y
Genetic
Background		 involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6atm1.1Kaig mutation (1 available); any Kdm6a mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:190157 )
• mice are indistinguishable from wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory