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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kdm6atm1.1Kaig
targeted mutation 1.1, Kai Ge
MGI:5448754
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kdm6atm1.1Kaig/Kdm6atm1.1Kaig involves: 129S4/SvJaeSor MGI:5448829
cn2
 		Kdm6atm1.1Kaig/Kdm6atm1.1Kaig
Pax7tm2.1(cre/ERT2)Fan/Pax7+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5779968
cn3
 		Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
Kdm6atm1.1Kaig/Y
Pax7tm2.1(cre/ERT2)Fan/Pax7+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5779969
cn4
 		Kdm6atm1.1Kaig/Y
Pax7tm2.1(cre/ERT2)Fan/Pax7+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5779970
ot5
 		Kdm6atm1.1Kaig/Y involves: 129S4/SvJaeSor MGI:5488641


Genotype
MGI:5448829
hm1
Allelic
Composition		 Kdm6atm1.1Kaig/Kdm6atm1.1Kaig
Genetic
Background		 involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6atm1.1Kaig mutation (1 available); any Kdm6a mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:190157 )
• mice are indistinguishable from wild-type mice




Genotype
MGI:5779968
cn2
Allelic
Composition		 Kdm6atm1.1Kaig/Kdm6atm1.1Kaig
Pax7tm2.1(cre/ERT2)Fan/Pax7+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6atm1.1Kaig mutation (1 available); any Kdm6a mutation (40 available)
Pax7tm2.1(cre/ERT2)Fan mutation (1 available); any Pax7 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal muscle precursor cell morphology ( J:232700 )
• muscle progenitor cells fail to differentiate ex vitro
impaired skeletal muscle regeneration ( J:232700 )
• following CTX-induced muscle injury, tamoxifen-treated mice exhibit decreased myofiber density with increased necrotic tissues and inflammatory cell infiltration compared with control mice
• however, mice exhibit regeneration of smaller caliber myofibers




Genotype
MGI:5779969
cn3
Allelic
Composition		 Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
Kdm6atm1.1Kaig/Y
Pax7tm2.1(cre/ERT2)Fan/Pax7+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo mutation (10 available); any Gt(ROSA)26Sor mutation (993 available)
Kdm6atm1.1Kaig mutation (1 available); any Kdm6a mutation (40 available)
Pax7tm2.1(cre/ERT2)Fan mutation (1 available); any Pax7 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
impaired skeletal muscle regeneration ( J:232700 )
• in tamoxifen-treated mice following CTX-induced muscle injury




Genotype
MGI:5779970
cn4
Allelic
Composition		 Kdm6atm1.1Kaig/Y
Pax7tm2.1(cre/ERT2)Fan/Pax7+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6atm1.1Kaig mutation (1 available); any Kdm6a mutation (40 available)
Pax7tm2.1(cre/ERT2)Fan mutation (1 available); any Pax7 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal muscle precursor cell morphology ( J:232700 )
• muscle progenitor cells fail to differentiate ex vitro
impaired skeletal muscle regeneration ( J:232700 )
• following CTX-induced muscle injury, tamoxifen-treated mice exhibit decreased myofiber density with increased necrotic tissues and inflammatory cell infiltration compared with control mice
• however, mice exhibit regeneration of smaller caliber myofibers




Genotype
MGI:5488641
ot5
Allelic
Composition		 Kdm6atm1.1Kaig/Y
Genetic
Background		 involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6atm1.1Kaig mutation (1 available); any Kdm6a mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:190157 )
• mice are indistinguishable from wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory