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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rictortm1.1Klg
targeted mutation 1.1, Kun-Liang Guan
MGI:5448837
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rictortm1.1Klg/Rictortm1.1Klg
Tg(Mx1-cre)1Cgn/0 		B6.Cg-Rictortm1.1Klg Tg(Mx1-cre)1Cgn MGI:5448842


Genotype
MGI:5448842
cn1
Allelic
Composition		 Rictortm1.1Klg/Rictortm1.1Klg
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 B6.Cg-Rictortm1.1Klg Tg(Mx1-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rictortm1.1Klg mutation (2 available); any Rictor mutation (141 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:189736 )
N
• mice exhibit the normal frequency of mature T cells
decreased T cell proliferation ( J:189736 )
• cell-intrinsic reduction of DN3 and DN4 thymocyte proliferation without an increase in apoptosis
abnormal double-negative T cell morphology ( J:189736 )
• the percentage of DN3 is increased while the percentage of DN1 and DN4 cells is reduced
decreased single-positive T cell number ( J:189736 )
• of mature T cells in the thymus

hematopoietic system
hematopoietic system phenotype ( J:189736 )
N
• mice exhibit normal adult hematopoiesis
decreased T cell proliferation ( J:189736 )
• cell-intrinsic reduction of DN3 and DN4 thymocyte proliferation without an increase in apoptosis
abnormal double-negative T cell morphology ( J:189736 )
• the percentage of DN3 is increased while the percentage of DN1 and DN4 cells is reduced
decreased single-positive T cell number ( J:189736 )
• of mature T cells in the thymus

endocrine/exocrine glands

cellular
decreased T cell proliferation ( J:189736 )
• cell-intrinsic reduction of DN3 and DN4 thymocyte proliferation without an increase in apoptosis




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory