About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Krt18-EGFP,-TAg121)36Ysng
transgene insertion 36, Yurong Song
MGI:5449063
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Tg(Krt18-EGFP,-TAg121)36Ysng/0 involves: C57BL/6 * DBA/2 MGI:5617493
cn2
Tg(Krt18-EGFP,-TAg121)36Ysng/0
Trp53tm1Brn/Trp53tm2Tyj
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N MGI:5617494
cn3
Brca1tm1Brn/Brca1tm1Brn
Tg(Krt18-EGFP,-TAg121)36Ysng/0
Trp53tm1Brn/Trp53tm2Tyj
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N MGI:5617496
cn4
Brca2tm1Brn/Brca2tm1Brn
Tg(Krt18-EGFP,-TAg121)36Ysng/0
Trp53tm1Brn/Trp53tm2Tyj
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N MGI:5617497
cn5
Tg(Krt18-EGFP,-TAg121)36Ysng/0
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N MGI:5617495
cn6
Brca1tm1Brn/Brca1tm1Brn
Tg(Krt18-EGFP,-TAg121)36Ysng/0
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N MGI:5617499


Genotype
MGI:5617493
cn1
Allelic
Composition
Tg(Krt18-EGFP,-TAg121)36Ysng/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• when cre-expressing adenovirus is introduced under the bursa, 72% of ovaries exhibit cytologic abnormalities in the ovarian surface epithelium
• 27% of mice injected with cre-expressing adenovirus under the bursa develop minimal to mild atypical hyperplasia with occasional papillary epithelial projections 3 to 24 months postinduction
• mice injected with cre-expressing adenovirus under the bursa develop ovarian surface epithelium proliferation with progression only to stage I of ovarian cancer
• 27% of mice injected with cre-expressing adenovirus under the bursa develop ovarian surface epithelium carcinoma in situ with no invasion into the underlying ovary or overlying bursa
• 18% of mice injected with cre-expressing adenovirus under the bursa exhibit ovarian tumors that progress to serous epithelial ovarian cancer pathology with early invasion into ovary and bursa

reproductive system
• when cre-expressing adenovirus is introduced under the bursa, 72% of ovaries exhibit cytologic abnormalities in the ovarian surface epithelium
• 27% of mice injected with cre-expressing adenovirus under the bursa develop minimal to mild atypical hyperplasia with occasional papillary epithelial projections 3 to 24 months postinduction
• mice injected with cre-expressing adenovirus under the bursa develop ovarian surface epithelium proliferation with progression only to stage I of ovarian cancer
• 27% of mice injected with cre-expressing adenovirus under the bursa develop ovarian surface epithelium carcinoma in situ with no invasion into the underlying ovary or overlying bursa
• 18% of mice injected with cre-expressing adenovirus under the bursa exhibit ovarian tumors that progress to serous epithelial ovarian cancer pathology with early invasion into ovary and bursa

neoplasm
• mice injected with cre-expressing adenovirus under the bursa develop ovarian surface epithelium proliferation with progression only to stage I of ovarian cancer
• 27% of mice injected with cre-expressing adenovirus under the bursa develop ovarian surface epithelium carcinoma in situ with no invasion into the underlying ovary or overlying bursa
• 18% of mice injected with cre-expressing adenovirus under the bursa exhibit ovarian tumors that progress to serous epithelial ovarian cancer pathology with early invasion into ovary and bursa

growth/size/body
• 27% of mice injected with cre-expressing adenovirus under the bursa develop minimal to mild atypical hyperplasia with occasional papillary epithelial projections 3 to 24 months postinduction




Genotype
MGI:5617494
cn2
Allelic
Composition
Tg(Krt18-EGFP,-TAg121)36Ysng/0
Trp53tm1Brn/Trp53tm2Tyj
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Krt18-EGFP,-TAg121)36Ysng mutation (0 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
Trp53tm2Tyj mutation (4 available); any Trp53 mutation (240 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 72% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

reproductive system
• 72% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

endocrine/exocrine glands
• 72% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
ovarian cancer DOID:2394 OMIM:167000
OMIM:607893
J:189304




Genotype
MGI:5617496
cn3
Allelic
Composition
Brca1tm1Brn/Brca1tm1Brn
Tg(Krt18-EGFP,-TAg121)36Ysng/0
Trp53tm1Brn/Trp53tm2Tyj
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Brn mutation (2 available); any Brca1 mutation (114 available)
Tg(Krt18-EGFP,-TAg121)36Ysng mutation (0 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
Trp53tm2Tyj mutation (4 available); any Trp53 mutation (240 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 70% of mice injected with a cre-expressing adenovirus (Ad-cre) under the bursa develop serous epithelial ovarian cancer pathology
• ovarian surface epithelium carcinomas that develop in mice intrabursally injected with Ad-cre show a range of morphologic patterns including papillary, micropapillary/filigree, microcystic, poorly differentiated adenocarcinoma, and solid/undifferentiated
• mice develop multifocal peritoneal carcinomatosis with tumor spread to all abdominal organs
• distant metastases are seen in the pleura of 87.5%, in the lung of 83% and in the liver of 46% of mutants intrabursally injected with Ad-cre that develop stage IV disease
• 2% of mice intrabursally injected with Ad-cre exhibit transformation of the oviduct epithelium, with lesions ranging from atypical hyperplasia, to carcinoma in situ to adenocarcinoma

reproductive system
• 70% of mice injected with a cre-expressing adenovirus (Ad-cre) under the bursa develop serous epithelial ovarian cancer pathology
• ovarian surface epithelium carcinomas that develop in mice intrabursally injected with Ad-cre show a range of morphologic patterns including papillary, micropapillary/filigree, microcystic, poorly differentiated adenocarcinoma, and solid/undifferentiated
• mice develop multifocal peritoneal carcinomatosis with tumor spread to all abdominal organs
• 2% of mice intrabursally injected with Ad-cre exhibit transformation of the oviduct epithelium, with lesions ranging from atypical hyperplasia, to carcinoma in situ to adenocarcinoma
• oviduct lesions are characterized by a glandular/acinar histology

homeostasis/metabolism
• ovaries in intrabursally Ad-cre injected mice show hemorrhagic or serous ascites

endocrine/exocrine glands
• 70% of mice injected with a cre-expressing adenovirus (Ad-cre) under the bursa develop serous epithelial ovarian cancer pathology
• ovarian surface epithelium carcinomas that develop in mice intrabursally injected with Ad-cre show a range of morphologic patterns including papillary, micropapillary/filigree, microcystic, poorly differentiated adenocarcinoma, and solid/undifferentiated
• mice develop multifocal peritoneal carcinomatosis with tumor spread to all abdominal organs

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
ovarian cancer DOID:2394 OMIM:167000
OMIM:607893
J:189304




Genotype
MGI:5617497
cn4
Allelic
Composition
Brca2tm1Brn/Brca2tm1Brn
Tg(Krt18-EGFP,-TAg121)36Ysng/0
Trp53tm1Brn/Trp53tm2Tyj
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2tm1Brn mutation (5 available); any Brca2 mutation (132 available)
Tg(Krt18-EGFP,-TAg121)36Ysng mutation (0 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
Trp53tm2Tyj mutation (4 available); any Trp53 mutation (240 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 68% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

endocrine/exocrine glands
• 68% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

reproductive system
• 68% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
ovarian cancer DOID:2394 OMIM:167000
OMIM:607893
J:189304




Genotype
MGI:5617495
cn5
Allelic
Composition
Tg(Krt18-EGFP,-TAg121)36Ysng/0
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Krt18-EGFP,-TAg121)36Ysng mutation (0 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 88% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

endocrine/exocrine glands
• 88% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

reproductive system
• 88% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
ovarian cancer DOID:2394 OMIM:167000
OMIM:607893
J:189304




Genotype
MGI:5617499
cn6
Allelic
Composition
Brca1tm1Brn/Brca1tm1Brn
Tg(Krt18-EGFP,-TAg121)36Ysng/0
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Brn mutation (2 available); any Brca1 mutation (114 available)
Tg(Krt18-EGFP,-TAg121)36Ysng mutation (0 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 78% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

reproductive system
• 78% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

endocrine/exocrine glands
• 78% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
ovarian cancer DOID:2394 OMIM:167000
OMIM:607893
J:189304





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory