Phenotypes associated with this allele

• Allele Symbol: Vsx2^tm1.1Itl
• Allele Name: targeted mutation 1.1, inGenious Targeting Laboratory
• Allele ID: MGI:5449355
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vsx2^tm1.1Itl/Vsx2^tm1.1Itl	involves: 129S6/SvEvTac	MGI:5449358
cx2	Mitf^Mi/Mitf^+ Vsx2^tm1.1Itl/Vsx2^tm1.1Itl	involves: 129S1/Sv * 129S6/SvEvTac	MGI:5449365

Genotype
MGI:5449358

hm1

• Allelic Composition: Vsx2^tm1.1Itl/Vsx2^tm1.1Itl
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Small eyes in various Vsx2 homozygous mutants

vision/eye

abnormal retina pigment epithelium morphology ( J:190452 )

• thickened

abnormal retina pigmentation ( J:190452 )

• ectopic pigmentation of the retina

small lens ( J:190452 )

abnormal retina development ( J:190452 )

• onset of neurogenesis is delayed by 1-2 days in the retina

microphthalmia ( J:190452 )

• by E11.5

• becomes progressively more severe with age

• similar in size to mice homozygous for Vsx2^or-J

decreased total retina thickness ( J:190452 )

pigmentation

abnormal retina pigment epithelium morphology ( J:190452 )

• thickened

abnormal retina pigmentation ( J:190452 )

• ectopic pigmentation of the retina

Genotype
MGI:5449365

cx2

• Allelic Composition: Mitf^Mi/Mitf⁺; Vsx2^tm1.1Itl/Vsx2^tm1.1Itl
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

The dominant negative Mitf^Mi allele restores retinal development in the Vsx2 mutants

vision/eye

abnormal eye morphology ( J:190452 )

• substantial improvements in eye size, tissue histology and retinal neurogenesis compared to mice homozygous for Vsx2^tm1.1Itl alone

abnormal eye size ( J:190452 )

• substantial improvements in eye size compared to mice homozygous for Vsx2^tm1.1Itl alone