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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nuggctm1Diaz
targeted mutation 1, Marilyn Diaz
MGI:5449547
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Nuggctm1Diaz/Nuggctm1Diaz
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: C57BL/6 * C57BL/6J * CBA MGI:5476766


Genotype
MGI:5476766
cn1
Allelic
Composition		 Nuggctm1Diaz/Nuggctm1Diaz
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (43 available)
Nuggctm1Diaz mutation (0 available); any Nuggc mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal somatic hypermutation frequency ( J:190402 )
• Peyer's patch B cells exhibit increased mutation frequency (G to C transitions) at JH4 downstream regions at immunoglobulin and non-immunoglobulin loci compared with wild-type cells

immune system
immune system phenotype ( J:190402 )
N
• mice exhibit normal B cell development, germinal center formation and class switch recombination
abnormal somatic hypermutation frequency ( J:190402 )
• Peyer's patch B cells exhibit increased mutation frequency (G to C transitions) at JH4 downstream regions at immunoglobulin and non-immunoglobulin loci compared with wild-type cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory