Phenotypes associated with this allele

• Allele Symbol: Pdcd1^tm1.1Liux
• Allele Name: targeted mutation 1.1, Xiaolong Liu
• Allele ID: MGI:5449635
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdcd1^tm1.1Liux/Pdcd1^tm1.1Liux	involves: C57BL/6	MGI:5449726
cn2	Pdcd1^tm1.1Liux/Pdcd1^tm1.1Liux Tg(MMTV-PyVT)634Mul/0	involves: C57BL/6 * FVB/N	MGI:5449727

Genotype
MGI:5449726

hm1

• Allelic Composition: Pdcd1^tm1.1Liux/Pdcd1^tm1.1Liux
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Decreased tumor growth in Pdcd1^tm1.1Liux/Pdcd1^tm1.1Liux mice following carcinoma cell inoculation

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:190150 )

neoplasm

decreased tumor growth/size ( J:190150 )

• decreased lung tumor number and growth following inoculation with Lewis lung carcinoma or B16-F10 melanoma

immune system

increased T-helper 1 cell number ( J:190150 )

• in tumor following inoculation with Lewis lung carcinoma

decreased regulatory T cell number ( J:190150 )

• in tumor following inoculation with Lewis lung carcinoma

cellular

increased apoptosis ( J:190150 )

• in tumor cells following inoculation with Lewis lung carcinoma or B16-F10 melanoma

decreased cell proliferation ( J:190150 )

• in tumor cells following inoculation with Lewis lung carcinoma or B16-F10 melanoma

hematopoietic system

increased T-helper 1 cell number ( J:190150 )

• in tumor following inoculation with Lewis lung carcinoma

decreased regulatory T cell number ( J:190150 )

• in tumor following inoculation with Lewis lung carcinoma

Genotype
MGI:5449727

cn2

• Allelic Composition: Pdcd1^tm1.1Liux/Pdcd1^tm1.1Liux; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: involves: C57BL/6 * FVB/N

Reduced tumor growth in Pdcd1^tm1.1Liux/Pdcd1^tm1.1Liux Tg(MMTV-PyVT)634Mul/0 mice

mortality/aging

extended life span ( J:190150 )

• mice survive longer than Pdcd1⁺/Pdcd1^tm1.1Liux Tg(MMTV-PyVT)634Mul mice

neoplasm

decreased tumor growth/size ( J:190150 )

• reduced tumor growth compared to in Pdcd1⁺/Pdcd1^tm1.1Liux Tg(MMTV-PyVT)634Mul mice

increased tumor latency ( J:190150 )

• compared with Pdcd1⁺/Pdcd1^tm1.1Liux Tg(MMTV-PyVT)634Mul mice

immune system

increased T-helper 1 cell number ( J:190150 )

• in tumors 0447. smb 1/21/13

decreased T-helper 17 cell number ( J:190150 )

• in tumors

decreased T-helper 2 cell number ( J:190150 )

• in tumors

decreased regulatory T cell number ( J:190150 )

• in tumors

increased interferon-gamma secretion ( J:190150 )

• in tumor-infiltrating CD4+ and CD8+ T cells

decreased interleukin-17 secretion ( J:190150 )

• of Il17a in tumor-infiltrating CD4+ T cells

increased interleukin-2 secretion ( J:190150 )

• in tumor-infiltrating CD4+ and CD8+ T cells

increased tumor necrosis factor secretion ( J:190150 )

• in tumor-infiltrating CD4+ and CD8+ T cells

cellular

increased apoptosis ( J:190150 )

• of tumor cells compared to in Pdcd1⁺/Pdcd1^tm1.1Liux Tg(MMTV-PyVT)634Mul mice

hematopoietic system

increased T-helper 1 cell number ( J:190150 )

• in tumors 0447. smb 1/21/13

decreased T-helper 17 cell number ( J:190150 )

• in tumors

decreased T-helper 2 cell number ( J:190150 )

• in tumors

decreased regulatory T cell number ( J:190150 )

• in tumors