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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Il2tm1.1Kasm
targeted mutation 1.1, Kendall A Smith
MGI:5449713
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Il2tm1.1Kasm/Il2tm1.1Kasm
Ndor1Tg(UBC-cre/ERT2)1Ejb/?
involves: 129S/SvEv * C57BL/6 MGI:5449733


Genotype
MGI:5449733
cn1
Allelic
Composition
Il2tm1.1Kasm/Il2tm1.1Kasm
Ndor1Tg(UBC-cre/ERT2)1Ejb/?
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2tm1.1Kasm mutation (1 available); any Il2 mutation (43 available)
Ndor1Tg(UBC-cre/ERT2)1Ejb mutation (6 available); any Ndor1 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• normal increase in size and granularity of both CD4+ and CD8+ T cells after 5 days of tamoxifen treatment and activation with anti-CD3/28
• also normal increase in DNA replication in activated CD4+ and CD8+ T cells after 5 days of tamoxifen treatment and activation with anti-CD3/28
• after 5 days of tamoxifen treatment and activation with anti-CD3/28

cellular
• fail to switch from oxidative phosphorylation to aerobic glycolysis after 5 days of tamoxifen treatment and activation with anti-CD3/28

homeostasis/metabolism
• after 5 days of tamoxifen treatment and activation with anti-CD3/28





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory